Exploring the Therapeutic Potential of Phytochemicals Apigenin and Ellagic Acid in Managing Polycystic Ovarian Syndrome and Its Comorbidities: A Comprehensive Review

    November 2025 in “ Frontiers in Endocrinology ”
    Acharya Balkrishna, Maneesha Rana, Shalini Mishra … Shalini Singh
    Studysummary This review examines the potential of apigenin and ellagic acid as adjunct or alternative treatments for PCOS, but reports no new clinical results and highlights the need for further trials to confirm their efficacy and optimize dosing and delivery.
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    Research cited in this study 12

    1. Polycystic Ovary Syndrome and the Potential for Nanomaterial-Based Drug Delivery in Therapy of This Disease Pharmaceutics · 2024
    2. Randomized Clinical Trial of Astaxanthin Supplement on Serum Inflammatory Markers and ER Stress-Apoptosis Gene Expression in PBMCs of Women with PCOS Journal of Cellular and Molecular Medicine · 2024
    3. Ellagic Acid Inhibits Dihydrotestosterone-Induced Ferroptosis and Promotes Hair Regeneration by Activating the Wnt/Beta-Catenin Signaling Pathway Journal of ethnopharmacology · 2024
    4. Exploring the Antioxidative Effects of Ginger and Cinnamon: A Comprehensive Review of Evidence and Molecular Mechanisms Involved in Polycystic Ovary Syndrome and Other Oxidative Stress-Related Disorders Antioxidants · 2024
    5. Alternative Treatment of Polycystic Ovary Syndrome: Pre-Clinical and Clinical Basis for Using Plant-Based Drugs Frontiers in Endocrinology · 2024
    6. Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics Journal of Clinical Medicine · 2023
    7. Polycystic Ovary Syndrome: An Updated Overview Foregrounding Impacts of Ethnicities and Geographic Variations Life · 2022
    8. Effects of Low-Dose Spironolactone Combined with Metformin or Either Drug Alone on Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Pilot Study International Journal of Endocrinology · 2022
    9. Insulin Resistance and Elevated Androgen Levels: A Major Cause of Polycystic Ovary Syndrome Frontiers in Endocrinology · 2021
    10. Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies Clinical medicine insights · 2019
    11. Hormonal Contraceptives: Pharmacology Tailored to Women's Health Human Reproduction Update · 2016
    12. Health Care-Related Economic Burden of Polycystic Ovary Syndrome During the Reproductive Life Span The Journal of Clinical Endocrinology and Metabolism · 2005