Effects of Low-Dose Spironolactone Combined with Metformin or Either Drug Alone on Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Pilot Study

    March 2022 in “ International Journal of Endocrinology ”
    Tao Long, Ying Zhang, Chun‐Ping Zeng … Haiyan Liu
    Studysummary This study found that combining low-dose spironolactone with metformin improved insulin resistance in PCOS patients more effectively than using either drug alone.
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    Research cited in this study 11

    1. Comprehensive Overview of Polycystic Ovary Syndrome Nature Reviews Disease Primers · 2016
    2. American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1 Endocrine Practice · 2015
    3. Comparison of Spironolactone and Spironolactone Plus Metformin in the Treatment of Polycystic Ovary Syndrome Gynecological Endocrinology · 2015
    4. The Polycystic Ovary Syndrome: A Position Statement from the European Society of Endocrinology European Journal of Endocrinology · 2014
    5. Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology and Metabolism · 2013
    6. Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study The Journal of Clinical Endocrinology and Metabolism · 2013
    7. Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group Fertility and sterility · 2011
    8. Influence of Spironolactone Treatment on Endothelial Function in Non-Obese Women with Polycystic Ovary Syndrome European Journal of Endocrinology · 2011
    9. Spironolactone Versus Placebo or in Combination with Steroids for Hirsutism and/or Acne Cochrane library · 2009
    10. Evidence-Based and Potential Benefits of Metformin in Polycystic Ovary Syndrome: A Comprehensive Review Endocrine Reviews · 2008
    11. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS) Human Reproduction · 2003

    Related research 1

    1. Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome European journal of endocrinology · 2009