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GlossarySouthern blot

laboratory method to detect specific DNA sequences

Southern blot, also known as Southern hybridization, is a laboratory technique used to detect specific DNA sequences within a complex mixture. It involves transferring DNA fragments from an agarose gel onto a membrane, which is then probed with a labeled DNA probe that binds to the target sequence, allowing for visualization.

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Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System That Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice

research Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System That Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice

11 citations, October 2017 in “International Journal of Molecular Sciences”

A new drug delivery system using oil body-bound oleosin-rhFGF-10 improves wound healing and hair growth in mice.

Cloning of the Human Phenol Sulfotransferase Gene Family: Three Genes Implicated in the Metabolism of Catecholamines, Thyroid Hormones, and Drugs

research Cloning of the Human Phenol Sulfotransferase Gene Family: Three Genes Implicated in the Metabolism of Catecholamines, Thyroid Hormones, and Drugs

26 citations, February 1998 in “Chemico-Biological Interactions”

Scientists identified three genes important for processing certain brain chemicals, thyroid hormones, and medications.

research Transcriptome Analysis of Improved Wool Production in Skin-Specific Transgenic Sheep Overexpressing Ovine β-Catenin

4 citations, January 2019 in “International journal of molecular sciences”

Genetically modified sheep with more β-catenin grew more wool without changing the wool's length or thickness.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations, May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

688 citations, June 2007 in “Cell Stem Cell”

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

research WNT Signaling in the Control of Hair Growth and Structure

271 citations, March 1999 in “Developmental biology”

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

research Increased Copy Number of the TERT and TERC Telomerase Subunit Genes in Cancer Cells

145 citations, May 2008 in “Cancer Science”

Cancer cells often have more copies of TERT and TERC genes, which helps them grow and could affect patient outcomes.

research Ontogenetic Transition in Fetal Wound Transforming Growth Factor-Beta Regulation Correlates with Collagen Organization

109 citations, December 2003 in “American Journal of Pathology”

Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.

Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation

research Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation

108 citations, July 2002 in “Molecular and cellular biology”

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

research Quantitative Single-Cell Approaches to Stem Cell Research

106 citations, November 2014 in “Cell Stem Cell”

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

research Genetic Ablation of the CDP/Cux Protein C Terminus Results in Hair Cycle Defects and Reduced Male Fertility

97 citations, March 2002 in “Molecular and cellular biology”

Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.

research WNT10A Mutation Causes Ectodermal Dysplasia by Impairing Progenitor Cell Proliferation and KLF4-Mediated Differentiation

96 citations, June 2017 in “Nature Communications”

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

research Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene

94 citations, April 2002 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

Cloning of Wrinkle-Free, a Previously Uncharacterized Mouse Mutation, Reveals Crucial Roles for Fatty Acid Transport Protein 4 in Skin and Hair Development

research Cloning of Wrinkle-Free, a Previously Uncharacterized Mouse Mutation, Reveals Crucial Roles for Fatty Acid Transport Protein 4 in Skin and Hair Development

93 citations, April 2003 in “Proceedings of the National Academy of Sciences of the United States of America”

Fatty acid transport protein 4 is essential for skin and hair development.

research Keratinocyte-Specific Ablation of the NF-κB Regulatory Protein A20 (TNFAIP3) Reveals a Role in the Control of Epidermal Homeostasis

76 citations, May 2011 in “Cell death and differentiation”

A20 protein is crucial for normal skin and hair development.

research Defects in Mitochondrial DNA Replication and Oxidative Damage in Muscle of mtDNA Mutator Mice

53 citations, October 2014 in “Free radical biology & medicine”

Defective mitochondrial DNA replication causes aging symptoms and increased oxidative damage in mice.

research The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16

53 citations, September 1999 in “The journal of cell biology/The Journal of cell biology”

K16 can partially replace K14 but causes hair loss and skin issues.

Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

47 citations, April 2000 in “The American journal of pathology”

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

research Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-Like Growth Factor 1

33 citations, February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

IGF-1 increases whisker growth in transgenic mice.

research The Development of Several Organs and Appendages Is Impaired in Mice Lacking Sp6

32 citations, February 2008 in “Developmental dynamics”

Mice without the Sp6 gene have problems developing several body parts, including hair, teeth, limbs, and lungs.

Characterization and Chromosomal Localization of Human Hair-Specific Keratin Genes and Comparative Expression During the Hair Growth Cycle

research Characterization and Chromosomal Localization of Human Hair-Specific Keratin Genes and Comparative Expression During the Hair Growth Cycle

32 citations, February 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Two specific hair keratin genes are active during hair growth and decline as hair transitions to rest.

research Carriers of 21-Hydroxylase Deficiency Are Not at Increased Risk for Hyperandrogenism

31 citations, February 1997 in “The Journal of Clinical Endocrinology and Metabolism”

People who carry the 21-Hydroxylase Deficiency gene are not more likely to have excessive male hormone levels.

research The mRNA for Protease Nexin-1 is Expressed in Human Dermal Papilla Cells and its Level is Affected by Androgen

27 citations, September 1999 in “Journal of Investigative Dermatology”

Human skin cells contain Protease Nexin-1, and male hormones can decrease its levels, potentially affecting hair growth.

research Unveiling the Roots of Monogenic Genodermatoses: Genotrichoses as a Paradigm

26 citations, December 2011 in “Journal of Investigative Dermatology”

New gene identification techniques have improved the understanding and classification of inherited hair disorders.

The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

research The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

16 citations, December 2019 in “Animals”

Overexpressing Tβ4 in goats' hair follicles increases cashmere production and hair follicle growth.

CYP21A2 Genotypes Do Not Predict the Severity of Hyperandrogenic Manifestations in the Nonclassical Form of Congenital Adrenal Hyperplasia

research CYP21A2 Genotypes Do Not Predict the Severity of Hyperandrogenic Manifestations in the Nonclassical Form of Congenital Adrenal Hyperplasia

14 citations, January 2013 in “Hormone and Metabolic Research”

The severity of symptoms in nonclassical congenital adrenal hyperplasia is not determined by CYP21A2 gene variations.

Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia

research Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia

March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.

research Characterization, Genomic Organization, Expression, and Function of the mEphA1 Receptor Tyrosine Kinase

April 2024

mEphA1 receptor tyrosine kinase is important for skin and hair development and may play a role in certain diseases.

research C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny

338 citations, April 2001 in “Current Biology”

c-Myc activation in mouse skin increases sebaceous gland growth and affects hair follicle development.

research The Malignant Capacity of Skin Tumors Induced by Expression of a Mutant H-Ras Transgene Depends on the Cell Type Targeted

153 citations, April 1998 in “Current Biology”

The risk of skin tumors becoming malignant depends on the specific skin cell type affected.