4 citations
,
March 2020 in “BMC Research Notes” In this study of Irish adults with morbid obesity, skin tags were associated with higher blood pressure, HbA1c levels, and a greater prevalence of diabetes and hypertension, indicating increased cardiovascular risk.
1 citations
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January 2017 in “Przegla̧d dermatologiczny” This study found that patients with skin tags had a high prevalence of metabolic syndrome, prompting recommendations for screening underlying conditions like diabetes and hypertension.
August 2021 in “International Journal of Research in Dermatology” This study observed significant abnormalities in clinical and laboratory parameters related to metabolic syndrome among patients with skin tags.
January 2020 in “Research Square (Research Square)” In this study, Irish adults with severe obesity who had cervical or axillary skin tags showed higher systolic blood pressure, higher HbA1c levels, and more diabetes and hypertension, suggesting an increased vascular risk.
February 2020 in “Research Square (Research Square)” In this study, skin tags in Irish adults with morbid obesity were associated with higher blood pressure, higher HbA1c levels, and a greater prevalence of diabetes and hypertension, suggesting increased cardiovascular risk.
96 citations
,
January 1997 in “Clinics in Dermatology” This study found that G protein-coupled estrogen receptor enhances melanin synthesis in melanoma cells through cAMP-PKA-MITF-TYR signaling, suggesting its potential as a drug target for chloasma treatment.
64 citations
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June 1992 in “International Journal of Dermatology” Pregnancy often causes skin changes like darkening, stretch marks, and hair growth, which may improve after childbirth.
50 citations
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January 2013 in “Indian Journal of Dermatology” This review highlights the increasing association of metabolic syndrome with various dermatological conditions and suggests a link through chronic inflammation, oxidative stress, and endocrine abnormalities, yet reports no new findings.
47 citations
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May 2002 in “Journal of Cutaneous Medicine and Surgery” This review discusses normal skin changes during pregnancy such as pigmentary and glandular alterations, highlighting the need for physician awareness to avoid unnecessary treatments, and reports no new clinical findings.
45 citations
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September 2011 in “Journal of the European Academy of Dermatology and Venereology” This study found that obesity is associated with several skin conditions, such as striae and pseudoacanthosis nigricans, which may serve as markers of excessive weight.
27 citations
,
December 2016 in “Dermatology and Therapy” This review highlights the potential for clinicians to recognize skin manifestations as a straightforward method to detect insulin resistance and improve management of diabetes and obesity.
19 citations
,
January 2015 in “Indian Journal of Dermatology” In this study, researchers observed that 90% of patients with PCOS had cutaneous manifestations, with acne most common, and found associations between these skin conditions and high insulin or testosterone levels.
12 citations
,
March 2022 in “Frontiers in Nutrition” This review discusses the complex skin changes associated with obesity and the potential benefits of nutritional interventions for inflammatory skin diseases, without reporting new clinical results.
11 citations
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January 2013 in “Indian Journal of Endocrinology and Metabolism” This study concluded that mucocutaneous symptoms can assist in diagnosing diabetes mellitus and its complications, highlighting the potential for dermatologists to detect related systemic issues early in patients.
6 citations
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February 2014 in “Actas Dermo-Sifiliográficas” This study found that acanthosis nigricans and skin tags in nondiabetic, obese patients were significantly associated with higher insulin levels, suggesting they may serve as clinical markers of hyperinsulinemia.
3 citations
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May 2011 in “Practice nursing” As skin ages, it gets thinner, paler, and more wrinkled, and protection and care like sunblock and moisturizers are important.
1 citations
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December 2022 in “Gynecological Endocrinology” This study found that among women with PCOS, higher HOMA-IR levels were associated with acanthosis nigricans, and increased DHEA-SO4, FAI, and FI values were linked to hirsutism.
In this review, the authors discuss various skin conditions linked to hyperandrogenism, such as acne and alopecia, with a focus on androgen-targeted therapies, suggesting these are generally more effective than non-androgen-targeted options.
April 2026 in “Diagnostics” This study found that skin changes in morbidly obese individuals are associated with underlying metabolic disturbances but are not currently valuable as independent tools for assessing metabolic risk or treatment response.
April 2025 in “Indus journal of bioscience research.” This study observed that among patients with PCOS, hirsutism was present in 75.63%, acne in 65%, and other skin conditions such as female pattern hair loss, acanthosis nigricans, and seborrhea in varying proportions, highlighting the dermatological impact of PCOS on patients' quality of life.
January 2025 in “International Journal of Dermatology Venereology and Leprosy Sciences” This review article highlights that obesity is a significant risk factor for several inflammatory skin conditions, such as psoriasis and atopic eczema, contributing to increased overall morbidity among those affected.
September 2023 in “The Journal of Dermatology” In this 2-year prospective study, researchers observed that weight loss through bariatric surgery in patients with morbid obesity led to improvements in various skin conditions, although it also resulted in hair loss (telogen effluvium) for over half of the participants.
April 2023 in “Journal of Investigative Dermatology” In this study, bariatric surgery in patients with morbid obesity improved various skin conditions, although acute telogen effluvium was common, with notable reductions in facial sebum and skin elasticity changes.
May 2007 in “Bioline International (Bioline International)” This study reports that 91.4% of pregnant women in south India experienced pigmentary alterations, highlighting various skin changes occurring during pregnancy.
October 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the proprietary aptamer TAGX-0003 significantly inhibited IFNγ-induced effects in pre-clinical human models of alopecia areata, promoting hair regrowth and potentially preventing disease relapse.
45 citations
,
March 2020 in “International Journal of Nanomedicine” This study found that nanoemulsion-based formulations, such as nanoemulgel and NFs, might serve as promising topical delivery systems for treating inflammatory diseases, potentially offering an alternative to traditional nonsteroidal anti-inflammatory drugs, which are associated with adverse effects.
July 2013 in “Pharmaceutical Regulatory Affairs Open Access” This study reported that invasomes, utilizing limonene as a component, enhanced the transdermal permeation of finasteride by over 21 times, indicating their potential as a novel drug delivery system.
208 citations
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July 2001 in “Journal of The American Academy of Dermatology” This review discusses the classification and diagnosis of pregnancy-related skin conditions and reports no new clinical findings.
18 citations
,
September 2017 in “Clinics in Dermatology” This review highlights the role of dermatologists in detecting early cutaneous signs of obesity-related metabolic syndrome, which may enable earlier treatment to prevent long-term consequences; it reports no new clinical results.
7 citations
,
January 2011 in “Journal of The American Academy of Dermatology” This study observed that moderate to severe acne is the most common manifestation in women with hyperandrogenism and highlights acanthosis nigricans and hirsutism as useful clinical markers.