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The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.

Different types of skin cells play specific roles in development, healing, and cancer.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Particles around 100 nm can penetrate and stay in hair follicles without passing through healthy skin, making them safe for use in topical products and useful for targeted drug delivery.

The hydrogel with a 1:3 ratio of hydroxyethyl cellulose to hyaluronic acid is effective for delivering drugs through the skin to treat acne.

Pregnancy can cause skin pigmentation, stretch marks, and changes in hair, nails, and sweat glands, with most resolving after birth.

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

After menopause, women lose a lot of skin collagen, but estrogen replacement might improve skin health.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Minoxidil promotes hair growth by penetrating skin, with ethanol-containing formulas working best.

Some skin conditions may indicate metabolic syndrome, which could help with early detection and management of related health issues.

Ice-skating athletes often have skin problems due to cold, infections, and inflammation, needing careful treatment and prevention.

Men are more likely to get infectious skin diseases, while women are more prone to autoimmune and pigment-related skin conditions, influenced by biological and environmental factors.

Changes in skin microbes play a role in some skin diseases and could lead to new treatments.

Certain skin conditions may indicate or increase the risk of Parkinson's disease.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Menopause significantly reduces skin collagen, leading to thinner, less elastic skin, and hormone replacement may help but requires careful consideration.

Thyroid hormone affects skin health, with too little causing rough, pale skin and too much leading to smooth, thin skin, and may also impact wound healing and skin conditions.

Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.

Prolactin may be important for skin growth and immune function.

The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.

50-nm nanoparticles are better at penetrating skin and targeting hair follicles for drug delivery than 100-nm ones.

The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.

Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.

Adult skin quickly reacts to short-term environmental and internal stress, leading to various skin issues and the need for protective measures.

Nanoemulsion creams with certain enhancers can greatly increase caffeine delivery through skin.