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People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

Working night shifts for four days can lower the body's ability to use insulin, which may increase the risk of type 2 diabetes.

Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

Minoxidil lowers blood pressure, increases heart rate, and improves blood flow in dogs.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

DHT affects hair follicle cells by changing microRNA levels, leading to less cell growth and more cell death.

Researchers found a new gene variant linked to a rare bone disease, which doesn't always cause symptoms in carriers.

Isotretinoin improves severe acne without changing androgen or insulin levels but may increase body weight and triglycerides.

Metformin helps manage diabetes, PCOS, and weight in kids but needs more research for long-term safety.

A woman developed a severe skin reaction called toxic epidermal necrolysis after taking the antibiotic cephalexin.

Using rodents for research shows that health problems in the womb can cause diseases later in life.

Cantu syndrome, which causes excessive hair growth and skin issues, is due to a mutation in the ABCC9 gene, and understanding this could help develop new treatments for hair diseases.

Some sports supplements can cause health issues like mood swings, hair loss, and heart problems in men.

Si Jun Zi Tang may slow aging by affecting specific cell signaling pathways.

Estrogen deficiency, like after menopause or certain surgeries, leads to faster skin aging and health issues.

The analysis shows where minoxidil's atoms are likely to react and describes its electronic transitions and behavior with temperature changes.

Scientists in India found a safer and efficient way to make a type of medicine called hydantoins from carbamates, which also worked well in making the seizure medicine, Ethotoin.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Hair loss might be due to nerve issues, treatable with electric stimulation or acupuncture.

A 50-year-old woman with breast cancer developed an autoimmune skin disorder, highlighting the need for thorough checks and team-based treatment.

ADAM17 could be a potential target for treating PCOS.

Disrupting natural body clocks increases the risk of developing type 2 diabetes.

Patients with acne vulgaris have lower serum irisin levels.

Insulin resistance may contribute to hair loss in people with androgenic alopecia.

Ziziphus spina-christi leaf extract lowered blood sugar and protected organs in diabetic rats.

Metformin may help regulate periods and cause modest weight loss in PCOS patients, but more research is needed.

Frailer men have a higher risk of worsening prostate problems and serious health events needing hospital care.

Metformin helps manage weight, blood pressure, and hormonal imbalances in PCOS patients.

PCOS is a genetic disorder affecting women's reproductive health, with treatments focused on symptoms like insulin resistance and fertility.

The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.