Human Skin

The document from February 1, 2016, discussed the role of estrogen in skin aging, emphasizing that menopause and estrogen deficiency accelerate skin aging, leading to thinner skin, less collagen, more wrinkles, dryness, and decreased elasticity. A study by Toz et al. compared premenopausal women who had a hysterectomy with those who had a hysterectomy plus bilateral salpingo-oophorectomy (BSO), which causes estrogen deficiency. The study found significant skin deterioration in the BSO group at 24 and 48 weeks post-surgery, while the hysterectomy-only group did not show these changes, indicating estrogen's importance in skin health. However, the document also highlighted the complexities of estrogen therapy, including the risks and benefits, which complicates the use of systemic estrogen for skin health in premenopausal women considering elective oophorectomy.