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This study identified a crucial Gli2-Serpinh1 regulatory axis that regulates fibroblast state transitions during skin wound healing, shedding light on fibroblast heterogeneity and suggesting potential precision regenerative therapies.

This review discusses the use of single-cell RNA sequencing and spatial transcriptomics to enhance understanding of the pathogenesis and targeted therapies for chronic inflammatory skin conditions, highlighting technology advancements and the need for cost reduction and standardization.

This review outlines recent advancements in biomimetic materials for skin regeneration, emphasizing their potential to mimic tissue structures and regulate physiological processes, and discusses future directions involving novel technologies like artificial intelligence and in situ reprogramming.

The research aims to better understand hair follicle regulation and find new treatments for hair loss.

In this study, researchers found that inhibiting IKKα in patient-derived CCS tumour models reduces tumour viability, supporting the potential for topical IKKα inhibitors as a treatment for CCS.

This study used single-cell RNA sequencing to identify at least nine subpopulations of keratinocytes in human neonatal epidermis, revealing unexpected heterogeneity and complex differentiation trajectories.

This study investigated the molecular mechanisms of hair follicle morphogenesis in Ordos fine-wool sheep, identifying differential genes related to primary and secondary hair follicles, and providing important insights for improving wool quality and breeding strategies.

This study found that in mice with alopecia areata, CD8+ T cells showed clonal expansion and specific regulatory networks, which might help identify new therapeutic targets for patients not responding to JAK inhibitors.

This study explored the diversity of melanocyte stem cell subpopulations in the hair follicles of adult female mice and identified novel groups with distinct immune privilege regulation, suggesting a heterogeneous landscape that future research should consider.

This study found rapid changes in gene expression in mouse skin cells from the fetal to early postnatal stages, identifying specific markers for different fibroblast types and driver genes in dermal cell differentiation.

MultiKano accurately identifies cell types in complex data better than existing methods.

This review explains methods for studying chromatin variation at the single-cell level using scATAC-seq and discusses integrating these measures with other omics platforms but reports no new results.

In this study, researchers used transcriptomics and modeling to uncover previously unknown cell populations and marker genes in developing hair follicles, providing insights into early cell fate establishment and offering tools for further research on skin appendages.

In this study, researchers mapped gene expression in developing hair follicles to reveal unknown cell populations and markers, suggesting early establishment of cell fates in hair placodes.

This study found that human hair follicle-derived mesenchymal stem cells demonstrated enhanced wound healing capabilities compared to umbilical cord-derived stem cells in laboratory and animal models.

This study re-analyzed single cell RNAseq data and confirmed longstanding views on keratin gene regulation in keratinocytes, while challenging assumptions about their role in cellular differentiation states.

This study found that Krox20 marks a diverse stem cell population in mouse hair follicles, which significantly contributes to the interfollicular epidermis and regulates epidermal homeostasis.

This study details a step-by-step protocol for preparing mammalian skin samples, including hair follicles, for spatial transcriptomics to overcome challenges inherent in applying this technique to the skin.

This study constructed a comprehensive atlas of prenatal human skin, revealing that innate immune cells, such as macrophages, play a crucial role in skin morphogenesis by interacting with non-immune cells, influencing hair follicle formation and angiogenesis beyond their traditional immune functions.

This review highlights the roles of key transcription factors and signaling pathways in regulating olfactory epithelium regeneration, discussing recent advances in single-cell and spatial transcriptomics as well as organoid models to enhance understanding of olfactory regeneration mechanisms.

In this clinical trial, patients with lichen planopilaris treated with the oral TYK2 inhibitor deucravacitinib showed significant improvement in PGA, LPPAI, and Skindex-16 scores over 24 weeks, with transcriptomic analyses indicating decreased inflammatory and immune pathway activity post-treatment.

In this study, researchers observed distinct aging signatures in mouse keratinocytes, with increased expression in older mice, and noted relevant pathway changes that were also evident in human skin, suggesting potential insights into intrinsic skin aging.

This review highlights the development and assessment of human-relevant models for cutaneous wound healing, emphasizing that a combination of systems, such as organoid platforms and skin-on-a-chip systems, is necessary to overcome limitations of traditional methodologies and address chronic wound challenges.

EGFR-targeted cancer therapy can cause skin issues starting at hair follicles, leading to inflammation.

This review discusses the integration of omics analyses in androgenetic alopecia research, reporting no new clinical results but suggesting that collaborative multi-omics studies may enhance understanding of AGA's pathomechanisms.

This study identified CD201+ fibroblast progenitors in mouse skin that regulate wound healing through differentiation into specialized cell types, with retinoic acid and hypoxia influencing this process.

This study revealed key cellular dynamics and interactions during early embryonic mouse skin development, highlighting complex transitions from precursor states to diverse multilayered structures.

This review discusses the role and plasticity of epidermal stem cells in skin maintenance, wound repair, and cancer, noting recent insights from advanced technologies but providing no new clinical results.

Miniaturized hair follicles in androgenetic alopecia show abnormal mitochondrial activity and damage.

This study, using a reporter mouse line, characterized diverse subtypes of dopaminergic neurons in the enteric nervous system, identifying unique subtypes with potential roles in gut function and disease.