Hair Follicle Epithelial Stem Cells Contribute to Interfollicular Epidermis During Homeostasis

    July 2025 in “ JCI Insight ”
    Elnaz Ghotbi, Edem Tchegnon, Ze Yu … Lu Q. Le
    Studysummary This study found that Krox20 marks a diverse stem cell population in mouse hair follicles, which significantly contributes to the interfollicular epidermis and regulates epidermal homeostasis.
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    Research cited in this study 12

    1. Hair Follicles Modulate Skin Barrier Function Cell Reports · 2024
    2. Identification of Hair Shaft Progenitors That Create a Niche for Hair Pigmentation Genes & development · 2017
    3. Plasticity of Epithelial Stem Cells in Tissue Regeneration Science · 2014
    4. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    5. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    6. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    7. Multipotent Nestin-Expressing Hair Follicle Stem Cells The Journal of Dermatology · 2009
    8. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    9. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    10. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    11. Nestin Expression in Hair Follicle Sheath Progenitor Cells Proceedings of the National Academy of Sciences · 2003
    12. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000

    Related research 1

    1. The Effect of Flavonoids on Regenerated Hair Follicles with Pigmentation Journal of Dermatological Science · 2017