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Young female Australian fur seals are losing hair due to low tyrosine and zinc levels and high pollution exposure.

Climate-related nutritional stress may cause hair loss in juvenile male Guadalupe fur seals.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Sex hormone treatments can increase muscle mass in older adults but have inconsistent effects on muscle function and may carry cardiovascular risks.

Anabolic steroid users may face higher risk of severe COVID-19.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

PCOS may have evolved as an advantage in past environments with food scarcity.

Prenatal stress changes how male and female rats enjoy rewards differently, linked to sex hormones.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

A natural steroid in the body may protect against eye damage in glaucoma.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

Hair growth is influenced by factors like genetics and nutrition, and more research is needed to understand hair loss and growth mechanisms.

Finasteride reduces inflammation and improves immune response after trauma by altering hormone levels.

HSD3B1 gene variant and being overweight linked to hair loss in women with polycystic ovary syndrome.

Men, particularly those with hair loss, are more likely to get the virus, and those with prostate cancer may have milder symptoms. Testosterone's role in the disease is unclear, and the virus doesn't seem to harm male fertility. Women with PCOS might be at higher risk. More research is needed.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Effective treatments for spinal and bulbar muscular atrophy are not yet available; more research is needed.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

Managing side effects of endocrine therapy is crucial to improve adherence and survival in breast cancer patients.

Androgen receptors in the mouse brain may explain cognitive and mood changes in prostate cancer treatment.