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Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Women may need different blood pressure guidelines than men for heart disease prevention.

Men and women have different levels and production of brain steroids, which may affect their risk for certain brain disorders.

Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.

Hormones and sex affect potassium channel gene expression in electric fish, influencing their communication signals.

Male mice are more susceptible to autism-like changes from valproic acid than female mice.

ALRV5XR effectively promotes hair regrowth in both men and women through different mechanisms.

Men and women react differently to opioids, with hormones potentially influencing these differences.

Men and women experience skin aging differently due to changes in sex hormone levels with age.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

Men and women respond differently to drugs for COVID-19, high cholesterol, and diabetes, which suggests a need for personalized treatments.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Women experience more side effects and have worse blood pressure control from hypertension treatments than men, despite using different medications.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Gonadal hormones may influence sex differences in play fighting in animals, but their effect on human spatial behavior is unclear and needs more research.

Male rats have more somatostatin neurons than females due to testosterone converting to estrogen during early development.

People with androgenetic alopecia have different lipid levels in their blood, which vary between men and women, and may be linked to a higher risk of metabolic syndrome.

Finasteride reduces alcohol withdrawal effects, especially in female mice.

Tranexamic acid reduces skin aging more in female mice.

Finasteride metabolism varies by age, sex, and P450 inducers, with males processing it faster.

Chromosomal differences affect how muscle cells respond to testosterone.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

More research is needed to understand sex and racial differences in long COVID.

Gendered social factors, not just biology, contribute to sex differences in adverse drug events.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.

The document concludes that there is a significant lack of reporting on the sex and age of cells in skin research, which could affect clinical trials and treatments.

Sex hormones like estrogen and testosterone may affect COVID-19 severity differently in men and women, potentially influencing prevention and treatment strategies.