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    Glossary Sensitization

    immune system becomes overly reactive to a substance

    Sensitization refers to the process by which the immune system becomes overly reactive to a substance, often leading to allergic reactions. For example, in the context of hair and scalp health, repeated exposure to certain hair dyes or chemicals can cause the immune system to recognize these substances as harmful, resulting in inflammation or allergic dermatitis upon subsequent exposures.

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    1. Sensitization to saw palmetto and minoxidil in separate topical extemporaneous treatments for androgenetic alopecia Australasian Journal of Dermatology · 2002 · 17 citations
    2. Sensitization and Clinically Relevant Allergy to Hair Dyes and Clothes from Black Henna Tattoos: Do People Know the Risk? An Uncommon Serious Case and a Review of the Literature Cosmetics · 2016 · 1 citations
    3. Sensitisation to ethylhexyl salicylate: Another piece of the frontal fibrosing alopecia puzzle Contact dermatitis · 2023 · 1 citations
    4. 50570 Irritation and sensitization potential of approved topical and transdermal delivery systems – A retrospective study Journal of the American Academy of Dermatology · 2024
    5. An Animal Model of Trichloroethylene-Induced Skin Sensitization in BALB/c Mice International journal of toxicology · 2015 · 36 citations
    6. Androgens Induce Nongenomic Stimulation of Colonic Contractile Activity through Induction of Calcium Sensitization and Phosphorylation of LC20 and CPI-17 Molecular Endocrinology · 2010 · 31 citations
    7. Renbök Phenomenon and Contact Sensitization in a Patient With Alopecia Universalis Archives of Dermatology · 2010 · 18 citations
    8. A systematic review on the treatment of pediatric severe alopecia areata by topical immunotherapy or Anthralin (contact sensitization) or low‐level light/laser therapy (LLLT): focus on efficacy, safety, treatment duration, recurrence, and follow‐up based on clinical studies Journal of Cosmetic Dermatology · 2021 · 17 citations
    9. Indications for Peripheral and Central Sensitization in Patients With Chronic Scalp Pain (Trichodynia) The Clinical Journal of Pain · 2012 · 16 citations
    10. The investigation and management of severe hyperandrogenism pre- and postmenopause: Non-tumor disease is strongly associated with metabolic syndrome and typically responds to insulin-sensitization with metformin Gynecological Endocrinology · 2008 · 14 citations
    11. Role of autoerythrocyte sensitization test in the diagnosis of recurrent spontaneous bruising Indian Dermatology Online Journal · 2023 · 4 citations
    12. Nitric Oxide Signal Transduction and Its Role in Skin Sensitization Biomolecules & therapeutics · 2023 · 1 citations
    13. Contact sensitization to hair care allergens in scalp seborrheic dermatitis: associations with disease severity and microbiota profiles Frontiers in Allergy · 2026
    14. Table 1_Contact sensitization to hair care allergens in scalp seborrheic dermatitis: associations with disease severity and microbiota profiles.docx Figshare · 2026
    15. Patterns of Sensitization and Cross-Reactivity in Hair Dye Allergy: An 18-Year Tertiary-Center Experience from Greece. PubMed · 2026
    16. Analysis of Common Treatment Drugs and Allergen Sensitization in Hair Loss Patients Journal of Cosmetic Dermatology · 2025
    17. Intranasal sensitization model of alopecia areata using pertussis toxin as adjuvant Frontiers in Immunology · 2024
    18. Features of sensitization in patients with alopecia areata, associated with atopic diseases Russian Journal of Allergy · 2024
    19. TRAIL sensitization of PC3 prostate cancer cells by doxorubicin can be blocked by the anti-oxidant N-acetyl-cysteine or by the iron chelator deferoxamine Clinical Cancer Research · 2006
    20. Vitiligo complicating diphencyprone sensitization therapy for alopecia universalis British Journal of Dermatology · 1995 · 47 citations
    21. Topical minoxidil sensitization in androgenic alopecia Contact Dermatitis · 1987 · 14 citations
    22. Mechanisms of proton inhibition and sensitization of the cation channel TRPV3 The Journal of General Physiology · 2020 · 15 citations
    23. Chitosan from Lucilia cuprina (Diptera: Calliphoridae) enhances sensitization to insulin treatment in a diabetic burn mice of wound healing Swedish Journal of BioScience Research · 2020 · 2 citations
    24. Combined Systemic and Cutaneous Ovalbumin–Aluminum Sensitization Triggers Thermal Hyperalgesia, Spinal Gliosis, and Nociceptive Nerve Fibers Sprouting in Mice Physiologia · 2025 · 1 citations
    25. Hapten‐induced lymphadenosis benigna cutis secondary to squaric acid dibutylester sensitization for alopecia areata The Journal of Dermatology · 2014 · 3 citations
    26. Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model International Journal of Molecular Sciences · 2020 · 2 citations
    27. Hair Cycle-Dependent Changes in Skin Immune Functions: Anagen-Associated Depression of Sensitization for Contact Hypersensitivity in Mice Journal of Investigative Dermatology · 1996 · 43 citations
    28. 1406 Environmental pathobiology of frontal fibrosing alopecia (FFA): A link between linalool sensitization and FFA development Journal of Investigative Dermatology · 2023
    29. Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models Archives of Toxicology · 2018 · 38 citations
    30. Allergic contact dermatitis from minoxidil Contact Dermatitis · 1995 · 32 citations