January 2026 in “International Journal of Pharmaceutical Quality Assurance” In this study, researchers observed that patients with Alopecia Areata had significantly lower serum zinc and higher copper levels compared to healthy controls, indicating a disrupted zinc-copper balance that may contribute to the disease's pathogenesis.
September 2025 in “Journal of Clinical Medicine” This study found that patients with vitiligo and alopecia areata had significantly higher serum granulysin levels compared to healthy controls, indicating a potential pathogenic role and suggesting that elevated levels may serve as a biomarker for monitoring disease activity, particularly in active vitiligo cases.
July 2022 in “International Journal of Health Sciences (IJHS) (En línea)” In this study, researchers found that serum dihydrotestosterone levels were significantly lower in individuals with Type 2 Diabetes compared to healthy controls, with 90% of diabetics displaying subnormal levels.
July 2022 in “Dermatology Reports” This review found a predominance of low serum zinc levels across various skin disorders, indicating possible value in further investigating zinc supplementation as an adjunctive therapy.
July 2022 in “Al-Mağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ” In this study, patients with alopecia areata had significantly lower serum zinc levels compared to healthy controls, with an inverse relationship between zinc levels and disease severity.
December 2021 in “Dermatology research” This study found that individuals with premature graying of hair had significantly lower serum levels of vitamin B12, ferritin, and calcium compared to those without premature graying.
August 2021 in “Benha Journal of Applied Sciences” This study found that biotin supplementation significantly improved hair loss in telegon effluvium patients with low serum biotin levels.
January 2020 in “Journal of Clinical Biochemistry and Nutrition” This study observed that lower serum zinc levels in patients with chronic liver disease were linked to a higher prevalence of symptoms like dermatitis, taste disorder, and alopecia, suggesting these symptoms may be associated with zinc deficiency.
March 2022 in “Benha Journal of Applied Sciences” This study found that individuals with androgenetic alopecia had significantly lower serum vaspin levels than healthy controls, suggesting vaspin deficiency might help detect early-stage androgenic alopecia.
January 2012 in “Vitamins & trace elements” This study observed that smokers and alcohol consumers with androgenetic alopecia had significantly lower serum levels of antioxidant vitamins, and these habits may trigger earlier onset of alopecia in susceptible individuals.
77 citations
,
September 1983 in “Acta Paediatrica” In this study, administering dexamethasone rapidly normalized elevated steroid levels in girls with premature adrenarche.
44 citations
,
May 2014 in “The American Surgeon” In this study, hair loss after laparoscopic sleeve gastrectomy was associated with zinc and iron levels, even within normal ranges, and a combined variable of zinc and iron predicted susceptibility to hair loss.
36 citations
,
October 2008 in “European journal of paediatric neurology” This study found that pediatric patients on valproic acid may experience hair loss due to reduced zinc and biotinidase levels within the first 3 months, with zinc depletion continuing to contribute by the 6th month.
24 citations
,
January 2012 in “Indian Journal of Dermatology, Venereology and Leprology” This study suggests that hypersensitivity and increased serum IgE levels might contribute to the pathogenesis of diffuse alopecia areata through intense local inflammatory infiltration.
18 citations
,
January 1985 in “Acta Obstetricia Et Gynecologica Scandinavica” In this study of hirsute women, researchers found that correlations between hirsutism and hyperandrogenism were observed only in patients with a low LH/FSH ratio.
12 citations
,
May 2005 in “Fertility and Sterility” This study suggests that insulin levels may influence ovarian volume in women with idiopathic hirsutism who have normal ovulatory cycles and androgen levels.
6 citations
,
April 2011 in “British journal of oral & maxillofacial surgery/British journal of oral and maxillofacial surgery” This study found that serum testosterone levels significantly increased during major head and neck surgeries in maxillofacial surgeons, influenced by factors like tumor size and procedural complexity.
3 citations
,
January 2017 in “Journal of Pakistan Association of Dermatology” This study found a significant association between low serum ferritin levels and nonscarring alopecia in women, suggesting the importance of addressing iron deficiency for treatment effectiveness.
3 citations
,
January 2007 in “Korean Journal of Pediatrics” This case study reported that zinc supplementation improved skin lesions and diarrhea in a 4-month-old breast-fed infant with transient acrodermatitis enteropathica, even though her serum zinc level was nearly normal.
2 citations
,
January 2015 in “Journal of Health Science” This study reported that iron deficiency was significantly more common in Saudi women with telogen effluvium compared to those without hair loss.
2 citations
,
January 2011 This study found that zinc levels were significantly decreased in both alopecia areata and vitiligo patients compared to controls, suggesting zinc may play an important role in the etiopathogenesis of these conditions.
1 citations
,
October 2022 in “Zenodo (CERN European Organization for Nuclear Research)” This study reported that low serum ferritin levels in pediatric patients with alopecia areata were associated with increased disease severity and longer duration.
December 2025 in “Obesity Surgery” In this study, researchers found that patients undergoing one-anastomosis gastric bypass experienced a greater incidence of low serum zinc levels and related symptoms, such as hair loss and delayed wound healing, compared to those undergoing sleeve gastrectomy.
October 2025 in “Nepal Journal of Dermatology Venereology & Leprology” This study conducted at Tribhuvan University Teaching Hospital found no significant correlation between serum testosterone levels and acne severity in adult female patients with acne, suggesting that serum testosterone is not a reliable marker of androgen excess in this sub-population.
October 2025 in “International Journal of Social health” This systematic review reported that among men taking finasteride for benign prostatic hyperplasia, total PSA levels decreased by 30% to 50%, and free PSA by up to 45%, with reductions in prostate volume and PSA density observed as well.
January 2024 in “The Egyptian Journal of Hospital Medicine (Print)” This study found that there was no statistically significant difference in serum zinc levels between patients with pattern hair loss and healthy controls, and concluded that zinc deficiency is unlikely to be a direct cause of androgenetic alopecia.
October 2023 in “Benha Journal of Applied Sciences” In this review, serum clusterin is highlighted as a promising diagnostic and prognostic marker for post-adolescent acne, suggesting its potential role in the inflammatory and immunological processes of the condition, although its exact mechanisms remain to be fully understood.
February 2023 in “Benha Journal of Applied Sciences” In this study, serum zinc levels in telogen effluvium patients showed no significant difference compared to healthy controls.
January 2023 in “International journal of clinical medicine” This study found that women with PCOS and androgenetic alopecia had significantly lower serum gelsolin levels compared to women with androgenetic alopecia but without PCOS.
July 2022 in “Al-Mağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ” In this study, patients with alopecia areata were found to have significantly lower serum zinc levels compared to healthy controls, and lower zinc levels were associated with more severe disease.