Serum Granulysin Levels in Vitiligo and Alopecia Areata: A Potential Biomarker for Disease Activity and Dermoscopic Evaluation

    September 2025 in “ Journal of Clinical Medicine ”
    Hayam Ali AlRasheed, Amira Aboelmakarem Korkor, Yasmina Ahmed El Attar … Zainab Abdel Samad Ibrahim
    Studysummary This study found that patients with vitiligo and alopecia areata had significantly higher serum granulysin levels compared to healthy controls, indicating a potential pathogenic role and suggesting that elevated levels may serve as a biomarker for monitoring disease activity, particularly in active vitiligo cases.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 15

    1. Novel Electrotrichogenic Device Promotes Hair Growth in Men With Androgenetic Alopecia: A Pilot Study Journal of Cosmetic Dermatology · 2025
    2. Alopecia Areata: Pathogenesis, Diagnosis, And Therapies MedComm · 2025
    3. Enhancing Hair Regrowth In Alopecia Areata: The Power Duo Of CO2 Fractional Laser And Bimatoprost Archives of Dermatological Research · 2025
    4. Pathogenesis and Regenerative Therapy in Vitiligo and Alopecia Areata: Focus on Hair Follicle Frontiers in Medicine · 2025
    5. A Systematic Review of Case Series and Clinical Trials Investigating Regenerative Medicine for the Treatment of Vitiligo Journal of Cosmetic Dermatology · 2024
    6. Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences International journal of molecular sciences · 2024
    7. Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies Current issues in molecular biology · 2024
    8. Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches Antioxidants · 2023
    9. A Mouse Model of Vitiligo Based on Endogenous Auto-Reactive CD8+ T Cell Targeting Skin Melanocyte Cell Regeneration · 2022
    10. Evaluation of Serum Levels of IL-6, IL-10, and TNF-a in Alopecia Areata Patients: A Systematic Review and Meta-Analysis Biomedical Research and Therapy · 2021
    11. Correlation Between Serum Granulysin Level and Clinical Activity in Patients with Alopecia Areata Before and After Tofacitinib Therapy Journal of Cosmetic Dermatology · 2020
    12. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    13. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    14. Vitiligo and Alopecia Areata: Apples and Oranges? Experimental Dermatology · 2013
    15. Serum Granulysin as a Possible Key Marker of the Activity of Alopecia Areata Journal of Dermatological Science · 2013