A Mouse Model of Vitiligo Based on Endogenous Auto-Reactive CD8+ T Cell Targeting Skin Melanocyte

    October 2022 in “ Cell Regeneration ”
    Daoming Chen, Zijian Xu, Jun Cui, Ting Chen
    TLDR A new mouse model effectively mimics vitiligo for research and drug testing.
    The study developed a mouse model for vitiligo that replicated key features of the disease, such as skin depigmentation and melanocyte loss, by activating endogenous autoreactive CD8+ T cells. This was achieved through the inoculation of B16F10 melanoma cells and depletion of CD4+ regulatory T cells. The model showed a 60-80% success rate in inducing depigmentation, with higher success in female mice, and was applicable to any C57BL/6 mouse strain. It provided a valuable tool for vitiligo research and drug discovery, allowing for the study of disease progression and potential therapeutic interventions.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 9 results

      community 1 Month Topical Minoxidil Only

      in Progress Pictures  72 upvotes 2 years ago
      The conclusion of the conversation is that the user plans to use topical minoxidil, ketoconazole shampoo, and a derma stamp for hair loss treatment. They also plan to start using finasteride in the next 2 months. Other users suggest using finasteride and a hair transplant for better results. The user appreciates the feedback and will continue posting progress.

      community 25M Exploring Causes of Hair Loss: TE, Alopecia, or AGA?

      in General  226 upvotes 3 months ago
      The user is experiencing hair loss with possible causes including chronic telogen effluvium, diffuse alopecia areata, and androgenic alopecia. They have tried treatments like Nizoral shampoo, minoxidil, and finasteride, and are considering a biopsy for further clarity.

      community One full year of treatment before and after

      in Progress Pictures  19 upvotes 1 year ago
      A user shared their one-year progress with hair loss treatment, using topical minoxidil, 2% keto shampoo, microneedling, and finasteride. They plan to start dutasteride and are considering switching to oral minoxidil.

      community Fighting Hair loss AND Grey Hair

      in Treatment  19 upvotes 3 years ago
      The user is treating hair loss with topical Minoxidil, Finasteride, RU58841, microneedling, and Ketoconazole. For grey hair, they use L-Cysteine, L-Methionine, and PABA, and have noticed some re-pigmentation.

    Similar Research

    5 / 1000+ results