A Mouse Model of Vitiligo Based on Endogenous Auto-Reactive CD8+ T Cell Targeting Skin Melanocyte

    October 2022 in “ Cell Regeneration ”
    Daoming Chen, Zijian Xu, Jun Cui, Ting Chen
    TLDR A new mouse model effectively mimics vitiligo for research and drug testing.
    The study developed a mouse model for vitiligo that replicated key features of the disease, such as skin depigmentation and melanocyte loss, by activating endogenous autoreactive CD8+ T cells. This was achieved through the inoculation of B16F10 melanoma cells and depletion of CD4+ regulatory T cells. The model showed a 60-80% success rate in inducing depigmentation, with higher success in female mice, and was applicable to any C57BL/6 mouse strain. It provided a valuable tool for vitiligo research and drug discovery, allowing for the study of disease progression and potential therapeutic interventions.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 11 results

      community fin 0.5 mg everday 6 months update

      in Finasteride/Dutasteride  28 upvotes 2 years ago
      The post discusses the experiences of individuals with diffuse hair thinning using finasteride, with many reporting no improvement or worsening conditions after 6 months. Various suggestions include persisting with the treatment, checking for underlying conditions, adding minoxidil for volume, adjusting dosage, and considering other potential causes like autoimmune responses and inflammation.

      community One full year of treatment before and after

      in Progress Pictures  18 upvotes 1 year ago
      A user shared their one-year progress with hair loss treatment, using topical minoxidil, 2% keto shampoo, microneedling, and finasteride. They plan to start dutasteride and are considering switching to oral minoxidil.

      community 1 Month Topical Minoxidil Only

      in Progress Pictures  72 upvotes 2 years ago
      The conclusion of the conversation is that the user plans to use topical minoxidil, ketoconazole shampoo, and a derma stamp for hair loss treatment. They also plan to start using finasteride in the next 2 months. Other users suggest using finasteride and a hair transplant for better results. The user appreciates the feedback and will continue posting progress.

      community Gland treatment and Crude Oil Massage

      in Treatment 7 years ago
      Hair loss treatment involves gland treatment with iodine, liver extract, wild American ginseng, and black cohosh, along with crude oil scalp massage. The approach aims to stimulate hormones and improve blood circulation to promote hair growth.

      community Making your own RT1640 in China

      in Research/Science 4 years ago
      RT1640, a combination of cyclosporin A, minoxidil, and RT175, is discussed as a potential treatment for hair regrowth and repigmentation. The unique formulation aims to enhance hair follicle growth and restore hair pigment without the negative side effects of immunosuppressants.

    Similar Research

    5 / 1000+ results