September 2025 in “SKINdeep” This study highlights the positive roles of sebaceous glands in skin health, including lubrication of hair follicles, delivery of antimicrobial lipids and vitamin E, and involvement in vitamin D conversion, contrasting their traditional association with skin conditions like acne.
23 citations
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October 2021 in “AAPS PharmSciTech”
December 2024 in “Research Journal of Pharmacy and Technology” The researchers investigated the potential of Suaeda maritima root extract for hair care and growth promotion. They reported high levels of saponins and antioxidants, showing significant biological activity in vitro, but noted a lack of anti-fungal effects against certain fungal species.
1 citations
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April 2018 in “Journal of Investigative Dermatology” In this study, OEA was found to significantly enhance sebaceous lipogenesis and potentially reduce inflammation in human sebocytes, suggesting it as a promising candidate for treating skin dryness.
3 citations
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August 2022 in “Pharmaceuticals” This study observed that a self-emulsifying drug delivery system for finasteride significantly enhanced bioavailability in rats compared to commercial tablets, but the formulation was found to be thermodynamically unstable.
September 2017 in “Journal of Investigative Dermatology” This study suggests that the newly characterized sebocytic progenitor cells HSGC1 and HSGC2 from different skin sites may have proliferative and differentiating potential in response to DHT.
21 citations
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November 2022 in “Clinical Cosmetic and Investigational Dermatology” This review highlights the potential of several medicinal plants as treatments for seborrhea dermatitis by inhibiting Malassezia growth and reducing symptoms like itching and redness, amid challenges of drug adherence and side effects in existing therapies.
January 2021 in “Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)” This review discusses recent findings related to sebaceous gland conditions, including updated recommendations for screening in sebaceous neoplasms and potential treatments for acne vulgaris, though no new definitive clinical results are reported.
58 citations
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March 2011 in “Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere/Pflügers Archiv” Hormones and signaling pathways control sebaceous gland function and could help treat acne.
35 citations
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April 1956 in “Journal of the American Medical Association” This study found that using selenium sulfide shampoo for seborrheic dermatitis was associated with hair loss, which ceased after discontinuing the shampoo.
19 citations
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March 2021 in “Experimental dermatology” This review discusses recent progress in understanding the cellular mechanisms of sebaceous gland development and maintenance, emphasizing the role of stem and progenitor cells in related skin pathologies, and reports no new results.
16 citations
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July 2012 in “Current pharmaceutical biotechnology” This review discusses the pathogenesis of common sebaceous gland diseases and their molecular pathways, but it reports no new clinical findings.
18 citations
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June 2012 in “Archives of Dermatological Research” This study found that treatment with vitamin D increased the expression of LL-37 through the vitamin D receptor in cultured sebocytes.
June 2023 in “Small animal advances” This case report describes successful treatment of mange in a rabbit using topical selamectin over two weeks.
This study found that theabrownin-selenium nanoparticles (TB-Se NPs) effectively target Malassezia-induced dermatitis through a dual antifungal and immunomodulatory mechanism, suppressing fungal overgrowth, reducing inflammation, and enhancing immune memory to prevent recurrence in a dermatitis model.
November 2005 in “CRC Press eBooks” This article reviews the development and challenges of skin penetration enhancers, highlighting their limitations in compatibility and safety, and reports no new clinical findings.
1 citations
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January 1988 In this study, topical dehydroepiandrosterone (DHEA) doubled sebum production in women without systemic side effects, suggesting it may be a safe treatment for reduced sebum output related to menopause.
97 citations
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September 2016 in “Reviews in Endocrine and Metabolic Disorders” This review summarizes recent multidisciplinary advances in sebaceous gland research and highlights potential novel therapeutic strategies for skin diseases, but it reports no new clinical results.
25 citations
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February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, topical application of the SCD1 inhibitor XEN103 significantly reduced sebaceous gland size and number in mouse skin, suggesting potential local therapeutic effects for acne treatment without systemic side effects.
June 2022 in “Zenodo (CERN European Organization for Nuclear Research)” This study evaluated a hydrogel containing extracts from azadirachta indica and tridax procumbens for treating seborrheic dermatitis, finding it passed various tests, including skin irritation and stability, suggesting potential future applications in herbal formulations.
1 citations
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January 2004 in “China Surfactant Detergent & Cosmetics” This study found that tea-seed saponin modified silicone polymer quaternary ammonium salt significantly improves hair conditioning performance in both dry and wet states when used in shampoo formulations.
June 2022 in “Farmacevtičnij časopis” This study developed a technology for a combined gel named "Biosedum Plus" intended for treating and preventing radiation skin damage, detailing its formulation and critical processing parameters.
August 2016 in “Journal of Investigative Dermatology” This study suggests that enhancing endocannabinoid tone with an EMT-inhibitor may have anti-inflammatory effects and slightly increase sebaceous lipid production, which could be beneficial for dry skin conditions.
July 2026 in “Clinical Cosmetic and Investigational Dermatology” In this study, a liposomal-encapsulated Sesbania grandiflora formulation significantly improved hair and scalp health in adults with hair loss over 180 days, showing enhanced hair density, thickness, growth rate, and tensile strength compared to placebo, with no related adverse events reported.
January 2026 in “Scientific Reports” In this study, researchers found that sesamin, a component of sesamum, modulated the AR-MAPK-Wnt signaling pathway in DHT-stimulated HaCaT keratinocytes, demonstrating potential multi-target activity against molecular events in androgenetic alopecia.
May 2026 in “Microorganisms” This study found that individuals with seborrheic alopecia had significant disruptions in their scalp microbiome, marked by imbalances in certain bacteria and fungi, and that a 12-week herbal shampoo intervention helped restore microbial diversity and improve clinical symptoms.
July 2024 in “Journal of Investigative Dermatology” ATR04-484 ointment shows promise for treating skin issues from cancer therapies.
198 citations
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January 1998 in “Dermatology” This review discusses human sebocyte in vitro models for studying sebaceous gland function and control but reports no new clinical results, highlighting hormonal effects and the impact of retinoids on sebocyte activity.
January 2022 in “Clinical Cases in Dermatology” This article reviews the causes, characteristics, and treatment options for seborrheic dermatitis, discussing its prevalence in specific populations, without providing new research findings.
July 2026 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that the liposomal Sesbania grandiflora formulation significantly improved hair and scalp health in adults with hair loss compared to placebo over 180 days, enhancing factors such as hair density, thickness, growth rate, and tensile strength, with no related adverse events reported.