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Anti-acne medications may work by reducing the activity of a protein involved in acne development.

A mutation in the KRT71 gene causes a hair disorder by disrupting hair follicle structure and texture.

Pangolins have lost some skin-related genes, but kept others, leading to their unique scales and skin features.

Caffeine can protect scalp hair follicles from damage caused by UV radiation.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Prostaglandin D₂ might be targeted for new male pattern baldness treatments.

Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.

Lipophilic dyes accumulate more in hair follicles when delivered with surfactant-propylene glycol solutions.

Finasteride shows promise for treating hair loss and excessive hair growth, but more research is needed to confirm its effectiveness and safety.

Acne and increased body hair in teenage girls are normal but severe cases may need hormone evaluation and treatment can prevent diabetes linked to PCO.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Using combined treatments can help manage acne by targeting the bacteria and skin changes that cause it.

ICG-enhanced NIR laser therapy may be a promising acne treatment with improvement and no side effects.

Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.

Isotretinoin effectively reduces acne but causes dry skin, higher skin pH, more redness, and hair loss.

Isotretinoin improves severe acne without changing androgen or insulin levels but may increase body weight and triglycerides.

Acne is caused by multiple factors including oil production, bacteria, inflammation, and possibly diet and environment.

Certain gene variations are linked to a higher risk of severe acne, suggesting a genetic influence on the condition.

The document explains various skin conditions and their treatments.

Genetic defects and UV radiation cause skin damage and aging.

Hair and nails are skin parts that develop early and serve protective and functional roles.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.