December 2024 in “World s Veterinary Journal” This case study from Ukraine describes a 5-year-old Akita dog diagnosed with sebaceous adenitis, presenting with pruritus, alopecia, and inflammation; treatment over 30 days led to complete restoration of affected areas, implicating potential heritability in Akitas.
April 2024 in “Journal of cutaneous pathology” In this case report, the authors identified that sebaceous gland atrophy, traditionally associated with psoriatic or drug-induced alopecia, can also appear in seborrheic dermatitis, complicating the histopathological evaluation of alopecia biopsies and emphasizing the need to consider seborrheic dermatitis in differential diagnoses.
August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identified a novel skin site called the follicular epidermis that is prone to cancer, with unique Axin2+ stem cells regulating its homeostasis. The findings suggest current therapeutic approaches may need reconsideration due to new insights into obstruction mechanisms at this site.
April 2023 in “Journal of Investigative Dermatology” This study found that sebaceous glands can regenerate after PPARg deletion in adult skin, relying on the hair cycle and FGFR signaling.
April 2023 in “Journal of Investigative Dermatology” This study found that while nicotinic acid significantly inhibited human sebaceous organoid growth in vitro, the predicted skin concentrations from gut microbiome-derived levels were far below the effective dose, suggesting high oral doses would be necessary for therapeutic effects.
April 2023 in “Journal of Investigative Dermatology” This study found that MPZL3 plays a crucial role in controlling sebaceous gland size and sebocyte proliferation in mice and humans, implicating its potential involvement in skin disorders like acne and psoriasis.
December 2022 in “Research Square (Research Square)” This study found that isotretinoin treatment significantly increased p53 expression in the skin of acne patients, inversely correlating with acne severity and body mass index.
November 2022 in “Journal of Investigative Dermatology” This study found that MPZL3 knockout mice showed reduced dermal white adipose tissue and increased sebocyte proliferation, suggesting a regulatory role for MPZL3 in lipid metabolism balance between adipocytes and sebocytes.
October 2022 in “Veterinária notícias/Veterinária Notícias” This case report describes a 5-year-old Akita with granulomatous sebaceous adenitis and pseudocyesis, who showed clinical remission and maintained a good quality of life after treatment with surgery and topical therapy.
October 2022 in “Boletín médico del Hospital infantil de México/Boletín médico del Hospital Infantil de México” This case report describes an 18-year-old male with a rare acquired smooth muscle hamartoma on his face, characterized by hyperpigmented plaques and increased hair growth, suggesting a histological overlap with folliculosebaceous cystic hamartoma.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study indicates that MPZL3 negatively regulates sebaceous gland size in mice by controlling sebocyte proliferation, with implications for disorders like acne and psoriasis.
May 2022 in “Research Square (Research Square)” This study found that isotretinoin treatment significantly increased p53 expression in the skin of acne vulgaris patients, which may help explain its effects on sebum production and adverse effects.
January 2021 in “Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)” This review discusses recent findings related to sebaceous gland conditions, including updated recommendations for screening in sebaceous neoplasms and potential treatments for acne vulgaris, though no new definitive clinical results are reported.
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, mouse sebaceous glands were found to require nerves for growth during active hair cycles, suggesting a nerve-dependent sebaceous gland cycle coordinated with hair growth.
August 2019 in “Journal of the American Academy of Dermatology” Frontal fibrosing alopecia may be caused by an autoimmune reaction and hormonal imbalance.
April 2019 in “Journal of Investigative Dermatology” This study found that induced COX-2 expression in adult transgenic mice led to hair follicle miniaturization and enlargement of sebaceous glands, and suggests that targeting the PGD2 pathway might reverse these effects.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” The authors concluded that Lrig1-positive stem cells are essential for sebaceous gland formation in mice, as their ablation led to temporary sebaceous gland disappearance without affecting hair growth.
April 2018 in “Journal of Investigative Dermatology” The researchers reported that nicotinic acid normalized excessive sebaceous lipogenesis without affecting basal lipogenesis and suggested potential anti-acne benefits.
April 2018 in “Journal of Investigative Dermatology” Mutations in Far2 mice cause hair loss due to sebaceous gland issues.
April 2017 in “Journal of dermatological science” This study found that while epidermal PLCγ1 is not necessary for keratinocyte differentiation in interfollicular epidermis, it is crucial for normal hair and sebaceous gland formation in mice.
January 2017 in “Springer eBooks” The document concludes that scalp health is influenced by complex factors affecting sebaceous glands, including hormones, aging, and various substances.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that sebaceous gland atrophy in psoriatic lesions correlates with the down-regulation of specific lipid biosynthetic gene modules, potentially affecting hair appearance without damaging follicles.
January 2016 in “Institutional Repositories DataBase (IRDB)” This study examined the expression of fatty acid transporters and binding proteins in mouse sebaceous glands and found that CD36 did not affect the localization of other related molecules.
In this study, the researchers observed that antiandrogen treatment with Cyproterone acetate led to atrophy of pilo-sebaceous units and may activate Langerhans cells, contributing to local inflammation.
This abstract discusses the classification of scarring alopecia, distinguishing it from secondary scarring alopecia and detailing its subtypes based on inflammation patterns and cells present during the disease's active phase, but reports no new clinical results.
December 2001 in “中華皮膚科醫學雜誌” This case report describes a rare instance of sebaceous trichofolliculoma identified in an 18-year-old boy, characterized by a dermal nodule on the nasal bridge with distinct histological features.
January 2009 in “Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei” January 1996 in “Springer eBooks” 12 citations
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April 2013 in “Clinical & experimental ophthalmology” This article does not include an abstract and reports no new clinical findings; it discusses Demodex blepharitis that mimics eyelid sebaceous gland carcinoma.
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November 2018 in “Curēus” This article reviews the occurrence of ectopic sebaceous glands in hair follicle matrix during hair embryogenesis and reports no new clinical results, indicating unknown pathogenesis and clinical implications.