Frontal Fibrosing Alopecia: Histopathological and Immunohistochemical Study of the Inflammatory Infiltrate and the Sebaceous Gland Receptors

    August 2019 in “ Journal of the American Academy of Dermatology ”
    TLDR Frontal fibrosing alopecia may be caused by an autoimmune reaction and hormonal imbalance.
    The study on frontal fibrosing alopecia (FFA) investigated the histopathological and immunohistochemical characteristics of the inflammatory infiltrate and sebaceous gland receptors. FFA is a type of primary scarring alopecia marked by the recession of the frontotemporal hairline and often affects postmenopausal women, suggesting a potential hormonal imbalance in its pathogenesis. The research indicated that an autoimmune reaction mediated by T lymphocytes might be involved. The clinical stabilization observed with oral antiandrogenic drugs further supported the hypothesis of hormonal involvement in FFA.
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