research Biofabrication of Human Skin with Its Appendages
Current methods can't fully recreate skin and its features, and more research is needed for clinical use.
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60-90 / 445 results research An Induced Pluripotent Stem Cell-Based Approach for Hair Follicle Development and Regeneration
iPSCs show promise for hair regeneration but need more research to improve reliability and effectiveness.
research Isolation of Epithelial Stem Cells from Dermis by a Three-Dimensional Culture System
Researchers isolated a new type of stem cell from mouse skin that can renew itself and turn into multiple cell types.
research Mapping the Establishment of Fibroblast Heterogeneity During Skin Development and Wound Repair
Skin heals with scars because only one type of fibroblast is used, not a mix.
research Mice Engrafted with Human Fetal Thymic Tissue and Hematopoietic Stem Cells Develop Pathology Resembling Chronic Graft-Versus-Host Disease
Mice with human fetal thymic tissue and stem cells developed symptoms similar to chronic graft-versus-host disease.
research CD8-Positive Lymphocytes in Graft-Versus-Host Disease of Humanized NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ Mice
CD8+ T cells play a key role in graft-versus-host disease in certain mice models.
research Alymphoid Cystic Thymic Dysgenesis - FOXN1 Gene Mutation: A Rare Case Report of Two Siblings
Two siblings had a rare immune disorder caused by a FOXN1 gene mutation.
research Alopecia Areata Update
Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.
research Regulation of Somatic Cell Reprogramming Through Inducible miR-302 Expression
Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.
research Progress and Prospects: Gene Therapy for Performance and Appearance Enhancement
Gene therapy shows promise for enhancing physical traits but faces ethical, safety, and regulatory challenges.
research Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies
Skin abnormalities can indicate immunodeficiency due to shared origins with the immune system.
research First Use of Thymus Transplantation Therapy for FOXN1 Deficiency (Nude/SCID): A Report of 2 Cases
Thymus transplantation successfully restored immune function in infants with FOXN1 deficiency.
research FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program
The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.
research FOXN1 Deficient Nude Severe Combined Immunodeficiency
FOXN1 gene mutations cause a rare, severe immune disease treatable with cell or tissue transplants.
research Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis
FOXN1 gene variants cause low T cells and immune issues from birth.
research Biological Significance of FoxN1 Gain-of-Function Mutations During T and B Lymphopoiesis in Juvenile Mice
FoxN1 overexpression in young mice harms immune cell and skin development.
research Current and Potential Agents for the Treatment of Alopecia Areata
Current and future treatments for alopecia areata focus on immunosuppression, immunomodulation, and protecting hair follicles.
research Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation
Thymic transplantation normalized some T-cells but not others, maintaining immune function.
research Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model
The humanized AA mouse model is better for testing new alopecia areata treatments.
research LB808: A Humanized Mouse Model of Androgenetic Alopecia (AGA) Shows That Platelet-Rich Plasma (PRP) Stimulates Hair Regrowth
Platelet-rich plasma (PRP) helps regrow hair in male pattern baldness.
research Vellus-to-Terminal Hair Follicle Reconversion in Male Pattern Balding in a New Humanized Mouse Model of Androgenetic Alopecia and Its Promotion by Minoxidil and PRP
Minoxidil and PRP can help convert miniaturized hair follicles back to normal in male pattern baldness.
research Effect of Minoxidil Formulations on Human Scalp Skin Xenotransplants on SCID Mice: A Novel Pre-Clinical In Vivo Assay for Androgenetic Alopecia Research
Minoxidil solution and foam both increase hair growth, but the solution works better than the foam.
research Mechanosensitive Lymphocytes Potentiate Wound Repair by Regulating Inflammation and Extracellular Matrix
Lymphocytes, a type of immune cell, are crucial for wound healing as they help remodel damaged areas and reduce inflammation.
research Mouse Models for the Study of Human Hair Loss
Mice are useful for researching human hair loss and testing treatments, despite some differences between species.
research Induction of Hair Follicle Neogenesis with Cultured Mouse Dermal Papilla Cells in De Novo Regenerated Skin Tissues
Scientists successfully grew new hair follicles in regenerated mouse skin using mouse and human cells.
research Evidence from a Humanized Mouse Model of Androgenetic Alopecia That Platelet-Rich Plasma Stimulates Hair Regrowth, Hair Shaft Diameter, and Vellus-to-Terminal Hair Reconversion In Vivo
PRP helps hair regrowth and thickness.
research The C3H/HeJ Mouse and DEBR Rat Models for Alopecia Areata: Review of Preclinical Drug Screening Approaches and Results
Both mouse and rat models are effective for testing alopecia areata treatments.
research Histologic Study of the Regeneration Process of Human Hair Follicles Grafted onto SCID Mice after Bulb Amputation
Human hair follicles can regenerate and recover after severe injury by going through a brief abnormal resting phase before growing again.
research Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage
Scientists turned mouse stem cells into skin cells that can grow into skin layers and structures.
research TCL1 Transgenic Mouse Model as a Tool for the Study of Therapeutic Targets and Microenvironment in Human B-Cell Chronic Lymphocytic Leukemia
The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.