Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, researchers found that inhibiting IKKα in patient-derived CCS tumour models reduces tumour viability, supporting the potential for topical IKKα inhibitors as a treatment for CCS.

In this study, BCC therapy reduced oxidative stress and cell damage in cardiomyocyte cells, suggesting it may serve as a new treatment alternative for heart disease.

In this study, researchers found that β-catenin directly promotes TERT expression in stem and cancer cells by interacting with the Tert promoter, illustrating a mechanistic link between tumorigenesis and pluripotency.

This report describes almost complete resolution of calcinosis and healing of associated ulcers in an 83-year-old woman with localized scleroderma after repeated intralesional steroid injections.

This study introduces a spherical skin model that effectively mimics key features of human skin, offering a scalable and rapid alternative for non-animal dermatological and cosmetic testing.

This study reports that in ovarian high-grade serous carcinoma, overexpressed S100A4 likely promotes epithelial-mesenchymal transition and cancer stem cell properties, affecting tumor behavior through its interaction with NMIIA and mutant p53.

This report highlights a new genetic variant of Woodhouse-Sakati syndrome in two sisters from the first identified family case in Russia, emphasizing the varied manifestations of the disorder and the importance of genetic testing for diagnosis and patient-specific treatment planning.

This overview details the Dermatologic Surgery journal's extensive coverage of dermatologic surgery topics, including cosmetic and reconstructive procedures, but it reports no new research findings.

This report describes three Saudi sisters with Woodhouse-Sakati syndrome, who exhibited typical features of the condition along with unusual gynecological anomalies.

Secukinumab reduces immune activity in hidradenitis suppurativa skin.

The Core Curriculum for Hair Restoration Surgery aims to improve doctor training for better, safer, and more natural-looking hair loss treatments.

CCCA affects Black men too, with a genetic link found in the PADI3 gene.

This study found that dysregulation of the DNA damage response in stem cells is a common factor of aging, affecting tissues like the skin, brain, kidneys, and intestine.

This case report describes how unique endoscopic findings led to the diagnosis of Satoyoshi syndrome coexisting with systemic lupus erythematosus and gastric adenoma, expanding the endoscopic understanding of the syndrome.

This study found that dermatologists in an urban academic setting most frequently use topical corticosteroids, intralesional corticosteroids, and topical minoxidil for treating central centrifugal cicatricial alopecia, aligning with current literature recommendations on reducing inflammation.

In this study, LC-OCT imaging was found to noninvasively identify specific features of cicatricial alopecia due to lupus erythematosus, such as hyperreflective collagen fibers, which may aid in distinguishing it from other types of scarring alopecia.

In this study, researchers found that knocking down the transcription factor Csdc2 inhibited the proliferation of dermal papilla cells in cashmere goats, and identified its regulatory relationship with the gene Robo2, providing insights into the genetic mechanisms influencing cashmere fiber growth.

This study highlights the phenotypic variability in 5 patients with Woodhouse-Sakati syndrome carrying the c.436delC mutation, suggesting a broader range of clinical presentations than previously recognized.

This case report described a woman in her 40s with ulcerative scalp sarcoidosis presenting in atypical skin locations, diagnosed with systemic sarcoidosis following comprehensive examination and histological analysis, and experiencing improvement with prednisone and hydroxychloroquine treatment.

This case report highlights the association of three CX26 gene mutations, particularly the D50N mutation, with keratitis–ichthyosis–deafness syndrome and its potential role in scalp squamous cell carcinoma and breast cancer development in a patient.

This study explores the role of cell competition in maintaining genomic quality in epidermal stem cells and proposes that this process might influence cancer development in skin tissues.

This study identified interactions between EGF signaling and the GLI proteins in basal cell carcinoma that may contribute to the limited metastasis seen in this skin cancer.

In this study, researchers identified significant differences in protein expression patterns in scalps affected by central centrifugal cicatricial alopecia, notably upregulation of immune pathways and fibrosis markers and downregulation of metabolic proteins, suggesting unique disease mechanisms and potential therapeutic targets.

This study identified a novel bi-allelic missense variant in the DSC3 gene linked to severe Hypotrichosis with Recurrent Skin Vesicles in a Saudi child, supporting its role in the condition.

This study observed that the NOTCH signaling pathway may contribute to the development of fibrosis in systemic sclerosis by affecting epithelial cell changes, and inhibiting this pathway could prevent fibrosis in experimental models.

This study reports that in systemic sclerosis, CD34+ dermal fibroblasts transition to CD34−, podoplanin+, and CD90+ fibroblasts across the dermis, suggesting a role in unchecked fibrosis.

This study found that autologous cell-based therapy using dermal sheath cup cells showed a moderate increase in hair volume in patients with pattern hair loss, particularly in women.

This study reports that the duration of hair loss is positively associated with the severity of central centrifugal cicatricial alopecia in African-American women.

This study suggests that NBCCS and BFHS may be the same genetic condition, which could help improve identification and management of misdiagnosed cases with specific surveillance strategies.