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330-360 / 1000+ resultsresearch Prefrontal 5α-reductase 2 mediates male-specific acute stress response
In this study, researchers observed that acute stress increased levels of the enzyme 5αR2 in the medial prefrontal cortex of male rats, affecting stress reactivity, but this effect was not seen in females.
research Sarcoptic mange in three alpacas treated successfully with amitraz
In this study, amitraz was found to be an effective and well-tolerated treatment for resolving sarcoptic mange in alpacas, demonstrating no relapse over a 10-month follow-up.
research In silico screening of Moroccan medicinal plants with the ability to directly inhibit the novel coronavirus, SARS-CoV-2
This study identified 29 Moroccan medicinal plants containing compounds that may act as natural inhibitors of SARS-CoV-2 based on molecular docking and in-silico analyses.
research Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment
This abstract reports funding sources for ongoing research and does not present any study results.
research Screening and identification of efficient strain in selenium oxyanions sorption in order to biological wastewater treatment
This study found that an Enterobacter isolate demonstrated high resistance to selenate and effective sorption capacity, suggesting potential for bioremediation of selenium-contaminated environments.
research Clinical picture, diagnosis, treatment and outcome of severe acute respiratory syndrome (SARS) in children
This review discusses the clinical features of SARS in children, noting milder symptoms compared to adults, and emphasizes the importance of ongoing monitoring for long-term effects; it reports no new treatment findings.
research Distribution of SALT scores by Therapeutic Tesponse in Patients with Severe Alopecia After 52 weeks of Baricitinib Therapy
This study found that at Week 52, baricitinib resulted in significant hair regrowth for many patients with severe alopecia areata, with 41.6% on the higher dose achieving substantial improvement in scalp hair loss, though some may need longer treatment for optimal benefit.
research Epidermal Differentiation Enhances CRABP II Expression in Human Skin
research Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes
This study found that novel androgen antagonists incorporating a carborane moiety showed anti-androgenic activity comparable to flutamide in a laboratory setting.
research Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing
This study found that the gene SRD5A1, associated with methylation changes due to early-life environment, may play a role in altering reproductive phenotypes in women by delaying pubertal onset and decreasing ovarian reserve.
research Study on the Activity of Sheep High-sulfur Keratin Promoter
This study found that the sheep high-sulfur keratin promoter B2C initiated GFP expression in sheep fibroblasts but remained inactive in mouse embryos.
research Development of a Visual Extension of the Severity of Alopecia Tool (VESALT) for Alopecia Areata
This study introduced and validated the VESALT, a visual extension of the Severity of Alopecia Tool, finding it offers improved reliability and user-friendliness over SALT by incorporating pattern recognition and broader coverage, including non-scalp regions, in assessing alopecia areata severity.
research 085 Coordinate expressions of cyclin-dependent kinase inhibitors and high sulfur protein in human hair follicles
research Co-Expression Pattern of Artemis Serine 516 Phosphorylation with Indicators Involving in Differentiation, Proliferation and Apoptosis of Human Anagen Hair Follicles: An Immunofluorescence Double-Staining Study
This study suggests that Artemis, particularly phosphorylated at serine 516, may have roles in hair follicle growth by influencing differentiation, proliferation, apoptosis, and cell cycling.
research Olfactory receptor OR2AT4 regulates human hair growth
This study found that stimulating the olfactory receptor OR2AT4 in human hair follicles with a synthetic sandalwood odorant promotes hair growth ex vivo by decreasing apoptosis and increasing IGF-1 production.
research Spectrum of skin diseases in Yemen (Hajjah and adjacent region)
This study found that over half of skin diseases observed in Yemen, particularly in Hajjah, were dermatitis and eczematous disorders, and infections, suggesting the influence of local socioeconomic and environmental factors.
research A Success Story of Cerebral Arteriovenous Malformation (AVM) Treated with Stereotactic Radiosurgery (SRS) in Bangladesh
This case report shares that a 25-year-old man with cerebral arteriovenous malformation was successfully treated with stereotactic radiosurgery in Bangladesh, achieving complete obliteration of the AVM without significant clinical symptoms.
research Sesamin alleviates androgenetic alopecia by targeting the AR MAPK Wnt axis
In this study, researchers found that sesamin, a component of sesamum, modulated the AR-MAPK-Wnt signaling pathway in DHT-stimulated HaCaT keratinocytes, demonstrating potential multi-target activity against molecular events in androgenetic alopecia.
research Segregation of Incomplete Achromatopsia and Alopecia Due to PDE6H and LPAR6 Variants in a Consanguineous Family from Pakistan
This study identified specific genetic variants as the cause of visual impairment and non-syndromic alopecia in two brothers, reinforcing the link between PDE6H variants and achromatopsia and LPAR6 variants and alopecia.
research Identification and expression of the target gene SLC24A2 of oar-miR-377 and its novel SNPs effects on wool traits in sheep
This study found that in sheep, the microRNA oar-miR-377 regulates hair follicle development by targeting the SLC24A2 gene, and identified a genetic variation associated with wool quality, suggesting potential markers for breeding.
research Serine palmitoyltransferase and peripheral neuropathy: studies on neuropathy-causing mutations and their biochemical hallmarks
This study concludes that dietary L-serine supplementation shows promise as a long-term therapy for hereditary sensory and autonomic neuropathy type 1, reducing neurotoxic 1-deoxysphingolipid levels and improving symptoms in severe cases.
research Genetic analysis of 5 α reductase type 2 enzyme in relation to oxidative stress in cases of androgenetic alopecia in a sample of egyptian population
This study found that individuals in this Egyptian cohort carrying the leucine (L) allele of the 5-α reductase type II enzyme had a higher risk of developing androgenetic alopecia, which may be associated with oxidative stress.
research Finasteride-related suicidal ideation reported to Lareb
research 567 Skin aging and carcinogenesis mechanisms by focusing on the stem cell competitive dynamics
This study explores the role of cell competition in maintaining genomic quality in epidermal stem cells and proposes that this process might influence cancer development in skin tissues.
research [Oral treatment of severe psoriasis with a new aromatic retinoid (Ro 10-9359) (author's transl)].
This study found that the aromatic retinoic acid derivative Ro 10-9359 provided excellent results in 64% of severe psoriasis patients, especially in those with erythrodermic and pustular types, though relapses and side effects were noted.
research 5 alpha-reductase and finasteride in pattern alopecia and acne.
research Possible role of autophagy activation in stimulation of regeneration
This study found that Satura Rosta Balm exerts a cytotoxic effect under oxidative stress and may trigger regeneration through autophagic pathways, despite not promoting proliferation or stress resistance in human cells.
research A 5α-reductase inhibitor, finasteride, increases differentiation and proliferation of embryonal carcinoma cell-derived-neural cells
research Hypotrichosis with Juvenile Macular Dystrophy in Saudi Arabia: A Case Report
This case report highlights a family member with a confirmed diagnosis of hypotrichosis with juvenile macular dystrophy due to a CDH3 gene mutation, emphasizing the importance of genetic testing for accurate counseling.