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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Finasteride doesn't effectively treat hair loss in postmenopausal women.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Chitin and chitosan are useful in cosmetics for oral care, haircare, and skincare, including UV protection and strength improvement.

The Rotterdam Study aims to understand various diseases in older adults.

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

PGD2 stops hair growth and is higher in bald men with AGA.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

Dermatologists need to understand hair products to treat hair and scalp issues better.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Demodicosis is common and often missed, needing more recognition and treatment in skin care.

Some medicinal plants can help heal wounds and may lead to new treatments.

Stem cell self-renewal is complex and needs more research for full understanding.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

Treating psoriasis on the scalp, nails, and skin folds is challenging, often requiring systemic treatments for severe cases, with some success in topical and biologic treatments.

A genetic region near the PAX1 gene is linked to a higher risk of scoliosis in females.

Nerves and chemicals in the body can affect hair growth and loss.

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.