Risk Factors for Prostate Cancer: A Case-Control Study Investigating Key Exposures and Gene Interactions

This study investigated the risk factors for prostate cancer, focusing on both environmental and genetic components. It highlighted age, race, and family history as established risk factors, while also exploring the potential roles of low-dose diagnostic radiation and surrogate hormone markers such as baldness, finger length pattern, and acne. The research emphasized the importance of genetics, particularly genetic polymorphisms, in the aetiology of prostate cancer. It examined single nucleotide polymorphisms (SNPs) related to DNA repair genes and hormone marker genes, suggesting that these genetic factors could interact with environmental exposures to influence prostate cancer risk.