Reduced Levels of Serum 25-Hydroxyvitamin D in Alopecia Areata: A Systematic Review and Meta-Analysis

April 2019 in “ Acta medica Philippina/Acta Medica Philippina ”

Felix Paolo J. Lizarondo, Patricia A. Nacianceno, Claudine Yap-Silva

alopecia areata serum 25-hydroxyvitamin D vitamin D deficiency vitamin D

TLDR People with alopecia areata often have lower vitamin D levels than healthy people.

The systematic review and meta-analysis conducted on studies published until July 2018 found that patients with alopecia areata had significantly lower levels of serum 25-hydroxyvitamin D compared to healthy controls. The meta-analysis included 11 studies with a total of 916 patients and revealed a pooled mean difference in serum vitamin D levels of -9.55 (95% confidence interval: -10.51 to -8.59) with high heterogeneity (I2=85%). The results suggest that vitamin D deficiency is more common in individuals with alopecia areata and that there is a trend towards lower vitamin D levels in more severe cases of the condition.

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