Reduced Levels of Serum 25-Hydroxyvitamin D in Alopecia Areata: A Systematic Review and Meta-Analysis

April 2019 in “ Acta medica Philippina/Acta Medica Philippina ”

Felix Paolo J. Lizarondo, Patricia A. Nacianceno, Claudine Yap-Silva

alopecia areata serum 25-hydroxyvitamin D vitamin D deficiency vitamin D

From the encyclopedia

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Vitamin D →

vitamin you should probably be taking for general health might also help your hair a little

Studysummary This study observed that patients with alopecia areata had significantly lower serum 25-hydroxyvitamin D levels than healthy controls, with a trend toward even lower levels in more severe cases. Our plain-language summary of this paper — not a Tressless recommendation.

The systematic review and meta-analysis conducted on studies published until July 2018 found that patients with alopecia areata had significantly lower levels of serum 25-hydroxyvitamin D compared to healthy controls. The meta-analysis included 11 studies with a total of 916 patients and revealed a pooled mean difference in serum vitamin D levels of -9.55 (95% confidence interval: -10.51 to -8.59) with high heterogeneity (I2=85%). The results suggest that vitamin D deficiency is more common in individuals with alopecia areata and that there is a trend towards lower vitamin D levels in more severe cases of the condition.

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Research cited in this study

9 / 9 results

research An Investigation of Vitamin D Status in Alopecia Areata

37 citations , June 2018 in “Clinical and Experimental Medicine”

This study found that patients with alopecia areata had significant systemic inflammation and vitamin D deficiency, with both conditions more pronounced as disease severity increased.

research Serum Vitamin D Level Is Related to Disease Severity in Pediatric Alopecia Areata

28 citations , April 2017 in “Journal of cosmetic dermatology”

This study found that while vitamin D deficiency is not the sole cause of alopecia areata, it may worsen the disease, suggesting supplementation could help in pediatric cases.

research Serum Level of Vitamin D in Patients with Alopecia Areata

13 citations , December 2016 in “Egyptian Journal of Basic and Applied Sciences”

This study found that patients with alopecia areata had significantly lower serum levels of 25-hydroxy vitamin D compared to control subjects.

research Assessment of Vitamin D Level in Patients with Alopecia Areata

12 citations , January 2016 in “Journal of Clinical and Investigative Dermatology”

This study examines how the Severity of Alopecia Tool score was used to assess Alopecia Areata in patients while excluding systemic conditions that might affect vitamin D levels, but reports no new clinical results.

research Vitamin D Deficiency in Alopecia Areata

105 citations , March 2014 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, patients with alopecia areata were found to have significantly lower serum vitamin D levels compared to those with vitiligo and healthy individuals, with lower levels correlating with increased disease severity.

Vitamin D and the Skin: Focus on a Complex Relationship

research Alopecia Areata Update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

This article reviews the clinical presentation and histopathologic features of alopecia areata and proposes a hypothesis for its development, but it reports no new clinical results.