724 citations
,
April 2004 in “Lancet Oncology” This review summarizes the use and neonatal outcomes of chemotherapy during pregnancy, noting its potential for safe use in the second and third trimesters, and reports no new clinical results.
451 citations
,
March 2005 in “Endocrine Reviews” This paper discusses the role of steroid sulfatase in hormone-dependent tumors and highlights the development of potent inhibitors, noting the commencement of a phase I trial for one inhibitor in postmenopausal breast cancer patients.
417 citations
,
September 2005 in “PLoS biology” This study developed molecular signatures for dermal papilla cells and their niche, uncovering novel signaling regulators and genes linked to hair disorders, which may inform future hair development research.
336 citations
,
August 2015 in “European Journal of Epidemiology” This article reviews the design and objectives of the Rotterdam Study, as well as summarizes major findings, without reporting new results.
266 citations
,
November 2013 in “European Journal of Epidemiology” This article outlines the rationale and design of the Rotterdam Study, summarizes its major findings, and updates its objectives and methods; it reports no new research results.
256 citations
,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that altering cell culture conditions to form three-dimensional papilla spheroids can restore the ability of human dermal papilla cells to induce hair growth in adult skin.
247 citations
,
August 2011 in “European Journal of Epidemiology” This article outlines the rationale, design, major findings, and updated objectives of the ongoing Rotterdam Study, without presenting new research data.
228 citations
,
September 2012 in “Trends in Neurosciences” This review examines the role of nerves in regeneration across various species and discusses their importance as components in the progenitor cell niche, reporting no new clinical results.
223 citations
,
October 2020 in “Microsystems & Nanoengineering” This review discusses recent advances in microfabrication and microfluidic technologies for improving the production of organoids and spheroids, but it reports no new experimental results.
219 citations
,
September 2009 in “European journal of epidemiology” This article discusses the rationale, design, major findings, and updated objectives and methods of the ongoing Rotterdam Study on various diseases, without reporting new research results.
184 citations
,
December 2018 in “Nature Communications” This study demonstrated that enhancing human skin constructs with hair follicles through engineered cell organization and vascularization improved hair growth in immunodeficient mice, suggesting potential advances for treating alopecia and chronic wounds.
136 citations
,
January 2013 in “International Journal of Trichology” This study found that adding microneedling to minoxidil treatment significantly improved hair growth in men with androgenetic alopecia compared to minoxidil alone across all assessed measures.
116 citations
,
September 2020 in “Nature Communications” This study reports previously unrecognized cellular complexity in growing mouse incisors, suggesting species-specific differences in cell dynamics between mouse and human teeth related to growth and differentiation.
101 citations
,
July 2021 in “Nature Communications” This study reported that 4D-printed, aliphatic polycarbonate-based scaffolds supported adipose tissue engineering by allowing adipocyte infiltration and neovascularization in vivo, indicating potential for effective adipose tissue repair.
98 citations
,
June 2001 in “Journal of biological chemistry/The Journal of biological chemistry” This study identified a cluster of genes on chromosome 17 related to hair keratin-associated proteins, including 37 genes forming seven multigene families, localized in the hair shaft's upper cortex.
97 citations
,
September 2016 in “Reviews in Endocrine and Metabolic Disorders” This review summarizes recent multidisciplinary advances in sebaceous gland research and highlights potential novel therapeutic strategies for skin diseases, but it reports no new clinical results.
93 citations
,
February 2015 in “Journal of Investigative Dermatology” This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.
88 citations
,
December 2018 in “Advanced Healthcare Materials” This review outlines the current state and future prospects of using layer-by-layer self-assembly for cell encapsulation in biomedical applications, such as cell-based biosensors, transplantation, and tissue engineering, while also discussing its limitations and potential advancements.
88 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This article reviews recent advancements in understanding and treating androgenetic alopecia, focusing on new genetic insights, stem cell roles, and diagnostic tools, without reporting new clinical results.
85 citations
,
October 2015 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that NF-κB signaling may connect injury response to regenerative processes in zebrafish hearts, potentially aiding the development of cardiac regenerative therapies in humans.
84 citations
,
February 2013 in “Clinica chimica acta” This review presents evidence that correlations exist between hair mineral imbalances and various diseases, though inconsistencies in results highlight the need for standardized preparation methods.
76 citations
,
May 2011 in “Cell death and differentiation” This study found that the enzyme A20 helps regulate EDAR-induced NF-κB signaling in mice, preventing ectodermal abnormalities like disheveled hair and assuring proper skin and appendage development.
71 citations
,
October 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study presents a novel in vitro assay using human folliculoid microspheres to research hair growth, which may facilitate preclinical testing of hair growth-modulatory agents.
70 citations
,
February 2015 in “Expert Opinion on Drug Discovery” This review discusses current knowledge on the biological mechanisms of different types of alopecia but reports no new clinical findings; the authors highlight future research directions, especially regarding epidermal stem cells and immune pathways.
68 citations
,
November 2011 in “The American journal of pathology” This review discusses the role of the hedgehog signaling pathway in hematological cancers and its potential as a therapeutic target; it reports no new clinical findings.
67 citations
,
April 2007 in “Journal der Deutschen Dermatologischen Gesellschaft” This article reviews the development and formulation of shampoos, emphasizing their dual role as cosmetic and medicinal products, but presents no new experimental findings.
66 citations
,
June 2018 in “International Journal of Women's Dermatology” This article discusses treatments for female pattern hair loss, highlighting that oral antiandrogens and topical minoxidil can effectively arrest progression and reverse miniaturization in many patients with mild-to-moderate cases, but it reports no new clinical results.
61 citations
,
June 2022 in “IEEE Journal of Biomedical and Health Informatics” This study introduced a novel deep clustering approach for melanoma detection from dermoscopic images, demonstrating improved performance over existing methods by mitigating class imbalance issues using a center-oriented margin-free triplet loss.
60 citations
,
June 2019 in “Ageing Research Reviews” This review discusses the potential of adipose-derived tissue components like nanofat and stem cells for aesthetic rejuvenation, covering their use in hair growth, scar reduction, and more, without reporting new clinical results.
60 citations
,
March 2011 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that RANK-RANKL signaling regulates hair renewal and epidermal homeostasis in mice, revealing its role in initiating hair growth cycles and maintaining skin cell activity.