2 citations
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January 2023 in “Eastern Journal Of Medicine” This review discusses the use, efficiency, and preparation methods of autologous platelet concentrates in wound healing and periodontal regeneration, but it reports no new clinical findings.
March 2026 in “Revista Ibero-Americana de Humanidades, Ciências e Educação” This systematic literature review found that exosome and PRP therapies show promise as effective, minimally invasive options for treating androgenetic alopecia, with clinical benefits potentially superior to or complementary to minoxidil, although standardization and larger clinical trials are needed to confirm long-term safety and efficacy.
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that inducing miR-205 reduces actin contractility and stiffness in hair follicle stem cells and progenitors, stimulating hair regeneration in both young and old mice.
5 citations
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November 2024 in “Advanced Science” This study reported the establishment of a chemically defined culture system that supports tooth reconstitution and detailed how co-stimulation of specific signaling pathways can sustain tooth development stages and initiate enamel formation, providing insights into tooth regeneration mechanisms.
6 citations
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October 2024 in “Frontiers in Bioengineering and Biotechnology” This study reported that the use of composite RGDmix hydrogel improved the survival and proliferation of human amniotic mesenchymal stem cells and increased growth factor expression, enhancing wound healing through the RGDSP/integrin αv/PI3K/AKT signaling pathway.
56 citations
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May 2017 in “Nature Cell Biology” Hair can regrow after certain stem cells are lost because other stem cells can take over their role.
This study found that elastin-like recombinamer (ELR) wound dressings promote tissue regeneration and stability without rejection in ex vivo and in vivo models, indicating potential for hard-to-heal wound treatment.
29 citations
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January 2021 in “Journal of nanobiotechnology” In this study, exosome-mimetic nanovesicles derived from neural progenitor cells promoted hair follicle regeneration in mice by activating the Wnt/β-catenin signaling pathway.
October 2015 in “Regenerative Medicine” This review highlights important studies in regenerative medicine, including one where PDGF and FGF2 synergistically maintained hair inductive potential in mouse dermal papilla cells in vitro, with potential implications for human hair loss therapy. It reports no new experimental results, focusing instead on existing research findings.
13 citations
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August 2007 in “Journal of Investigative Dermatology” Mouse hair can regrow in a special lab setup without serum.
16 citations
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June 2022 in “Acta biomaterialia” This study presents a bioprinter-based method for creating scalable, automated hair-inductive tissue grafts that showed improved hair shaft sprouting in mice by using suture guides to control orientation.
5 citations
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July 2023 in “World Journal of Stem Cells” In a study using a rat model, researchers developed injectable hydrogels from antler reserve mesenchyme which enhanced regenerative healing of full-thickness cutaneous wounds by creating a fetal-like niche that increased stem cell presence and modulated gene expression related to wound healing.
October 2024 in “Cosmetics” In this study, subthermal RF-CRET currents were found to alter key molecular mechanisms in dermal papilla cells, promoting proliferation and survival while enhancing markers associated with hair growth and maintenance, suggesting potential benefits for hair regeneration.
This review discusses advancements in regenerative medicine for hair loss treatments, highlighting stem cell techniques for rejuvenating or creating hair follicles, but provides no new clinical results.
2 citations
,
January 2022 in “Experimental Dermatology” This paper proposes that GDNF signaling may enhance skin regeneration and hair follicle formation by influencing dermal fibroblast differentiation, particularly following injury.
74 citations
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January 2013 in “Expert Opinion on Biological Therapy” This review discusses recent advances in hair follicle biology, regeneration, and tissue engineering, highlighting emerging therapeutic opportunities, and reports no new experimental results.
August 2025 in “Advanced Science” In this study, corrected data confirmed that AHFS seed microspheres exhibit good biocompatibility with fibroblasts, validating the initial results.
February 2026 in “Biomaterials” BOOST is a promising, easy-to-use treatment for diabetic foot ulcers that improves healing by reducing inflammation and promoting blood vessel growth.
This study found that late embryonic skin injuries can regenerate multiple tissue types, but this ability is hindered postnatally due to fibroblast-driven hyperinnervation, which can be mitigated to enable regeneration.
3 citations
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August 2025 in “Advanced Therapeutics” This review explores advancements in cytokine engineering for regenerative medicine, highlighting the development of modified cytokines with enhanced stability and tissue-targeting, potentially improving treatments for chronic wounds and fibrotic diseases by promoting tissue healing and minimizing inflammation, while adapting concepts from cancer immunotherapy.
November 2014 in “Journal of Cell Biology” Valentina Greco's research shows that the environment around hair follicle stem cells is more crucial for regeneration than the stem cells themselves.
1 citations
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June 2023 in “Journal of Visualized Experiments” This study describes a new intravital microscopy method for observing intestinal regeneration by tracking crypt dynamics in living mice after laser-induced tissue damage, revealing events like crypt fission, fusion, and disappearance over multiple weeks.
18 citations
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October 2014 in “In vitro cellular & developmental biology. Animal” Hair follicle stem cells can become neural cells using different methods, with varying efficiency.
12 citations
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January 2019 in “Regenerative Medicine” In this commentary, the authors discuss the challenges and proposals for responsibly translating regenerative therapies into clinical practice, emphasizing the need for patient education, quality control, and real-world evidence to validate these therapies and address ongoing misinformation in the field.
1 citations
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April 2016 in “PubMed” This study found that co-transplanting mouse epidermis and dermis cells induced new hair follicle formation, while isolated or cultured dermis cells contributed to follicle-related structures differently.
14 citations
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October 2012 in “Clinics in Plastic Surgery” Adding stem cells to fat grafts for facial rejuvenation might improve outcomes, but more research is needed to confirm safety and effectiveness.
3 citations
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July 2020 in “International Journal of Molecular Sciences” This study reported that molecules from Zebrafish embryo cell differentiation can counteract neurodegeneration, regenerate tissues, and potentially reverse hair follicle damage in androgenetic alopecia.
9 citations
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March 2022 in “Military Medical Research” This study developed a method to convert fibroblasts into sweat gland-like cells, suggesting potential for regenerating damaged skin and restoring sweat gland function.
12 citations
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October 2023 in “Tissue Engineering and Regenerative Medicine”
July 2023 in “Research Square (Research Square)” In an in-vitro study, researchers found that a specific concentration of Aloe Vera combined with injectable platelet-rich fibrin (i-PRF) significantly increased hair follicle stem cell proliferation compared to Aloe Vera or i-PRF alone, indicating potential benefits for alopecia treatment.