An Off-The-Shelf Bioactive EV Delivering Cryogel Orchestrating Immunomodulatory Reprogramming and Angiogenesis for Diabetic Ulcer Healing

    February 2026 in “ Biomaterials ”
    Parvaiz Ahmad Shiekh, Ubaid Tariq, Durga Nandini Athmuri, Prerna Singh, Jayanta Bhattacharyya, Ashok Kumar, Prajesh Nayak
    TLDR BOOST is a promising, easy-to-use treatment for diabetic foot ulcers that improves healing by reducing inflammation and promoting blood vessel growth.
    The study introduces BOOST, a multifunctional therapeutic platform designed for diabetic foot ulcers, combining oxygen delivery, antioxidant defense, and extracellular vesicle (EV) therapy. BOOST utilizes an oxygen-delivering cryogel scaffold with lyophilized EVs from adipose-derived stem cells, effectively modulating the wound microenvironment. It promotes immune modulation, angiogenesis, and reduces inflammation and oxidative stress, enhancing wound healing. The lyophilized EVs maintain their functionality without subzero storage, and the dressing remains effective after 6 months at 4°C. BOOST offers a promising, commercially viable, off-the-shelf solution for chronic wound treatment.
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