114 citations
,
March 2018 in “PLOS Medicine” This study found that women with polycystic ovary syndrome have higher rates of nonalcoholic fatty liver disease, with androgen excess contributing to the risk.
114 citations
,
January 2007 in “Drug Safety” This review discusses various adverse drug reactions affecting the skin, hair, and nails, emphasizing the importance of recognizing and reporting these reactions but reports no new clinical findings.
113 citations
,
April 1999 in “The Journal of Clinical Endocrinology and Metabolism” This study found that all four treatments—flutamide, finasteride, ketoconazole, and EE-CPA—significantly reduced hirsutism, but EE-CPA and flutamide appeared most effective, with varying effects on androgen levels and side-effect profiles.
112 citations
,
November 2023 in “Nano-Micro Letters” This review discusses the developments over the past five years in nanozyme-based theranostics for tumor therapy, including their classification, design, and synergistic strategies. It also outlines the challenges and prospects of using nanozymes to enhance selectivity, biosafety, repeatability, and stability in therapeutic applications.
111 citations
,
June 2002 in “The EMBO Journal” This study found that overexpression of Smad7 in transgenic mice led to severe alterations in multiple epithelial tissues, resulting in early death after birth.
111 citations
,
March 2012 in “Expert Opinion on Drug Delivery” This review discusses the potential use of liposomal formulations to enhance the effectiveness of cosmeceutical delivery through the skin barrier, with no new clinical results reported.
110 citations
,
April 2002 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.
109 citations
,
October 2007 in “Journal of pineal research” This study suggests that melatonin plays a role in hair follicle function by modulating growth and pigmentation, and it may act as a protective agent in active hair growth phases.
108 citations
,
August 2017 in “Clinical, Cosmetic and Investigational Dermatology” This review highlights microneedling's promise as an adjuvant therapy for enhanced drug delivery in dermatology, especially for conditions like atrophic scars and pigmentation disorders, though its efficacy for vitiligo is limited.
108 citations
,
January 2003 in “Fertility and Sterility” This study found that flutamide at 250 mg daily modestly improved hair thinning in premenopausal women with hyperandrogenic alopecia over one year, while cyproterone acetate and finasteride were not effective.
108 citations
,
July 2002 in “Molecular and cellular biology” This study found that overexpressing Dsg3 in the suprabasal epidermis of transgenic mice resulted in flaking skin and abnormal hair growth, supporting Dsg3's role in regulating epidermal differentiation.
107 citations
,
November 2008 in “The Journal of Rheumatology” This study found that fibromyalgia prevalence is slightly higher in patients with systemic lupus erythematosus compared to those with arthritis, but fibromyalgia-ness does not bias the SLE Activity Questionnaire.
106 citations
,
April 2010 in “ACS Nano” This study found that about 80% of known fullerene-binding proteins rank in the top 10% of scorers for C60 docking sites, confirming the accuracy of the predictive model used.
106 citations
,
June 2005 in “Journal of Investigative Dermatology” This study defines classification criteria for hair follicle dystrophy using a mouse model of chemotherapy-induced alopecia, providing tools for standardized hair damage assessment.
105 citations
,
February 2011 in “The Journal of Clinical Endocrinology & Metabolism” Treating sleep apnea in young obese women with PCOS can improve heart health and insulin sensitivity.
105 citations
,
January 2004 in “The Journal of Urology” This study found that finasteride significantly improved symptoms in CP/CPPS patients, except for voiding, unlike saw palmetto which showed no long-term benefits.
105 citations
,
September 1995 in “Journal of The American Academy of Dermatology” This review discusses the use of recombinant cytokines as therapeutic agents in clinical settings and describes the range of cutaneous complications associated with their use, including both minor and severe skin reactions.
104 citations
,
January 2014 in “Journal of Clinical and Experimental Dentistry” This review outlines the oral toxic effects of chemotherapy and stresses the need for evaluating dental health prior to treatment to mitigate these complications, but it reports no new clinical results.
104 citations
,
January 2005 in “Climacteric” This review discusses the pharmacological properties of progestins used in contraception and hormone replacement therapy, focusing on drospirenone's unique effects, but reports no new experimental findings.
100 citations
,
July 2004 in “The Journal of Sexual Medicine” This article reviews how various hormones may affect female sexual function and provides recommendations for diagnosing and treating endocrinologic sexual difficulties, but it reports no new clinical results.
100 citations
,
June 2002 in “Diabetologia” This study found that parents of women with PCOS have a higher prevalence of insulin resistance and Type II diabetes than parents of healthy women.
96 citations
,
October 2000 in “The FASEB Journal” In this study, researchers found that p75 neurotrophin receptor signaling affects apoptosis during hair follicle regression in mice, and altering its activity might help manage disorders involving early catagen entry.
96 citations
,
September 2008 in “Seminars in Cutaneous Medicine and Surgery” This review discusses the hormonal influences on acne's development in women and the therapeutic potential of hormonal treatments, but it reports no new clinical results.
94 citations
,
April 2002 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study describes the first case of female pseudohermaphroditism due to a novel homozygous glucocorticoid receptor gene mutation, indicating possible pre- and postnatal virilization in affected females.
93 citations
,
January 2016 in “British Journal of Dermatology” This study found that patients with acne vulgaris had higher serum IGF-1 levels and more intense FoxO1 and mTOR expression than controls, suggesting their role in acne pathogenesis.
93 citations
,
June 2001 in “The Journal of Clinical Endocrinology and Metabolism” This study found that serum androgen levels in premenopausal women may be influenced by genetic variants of the androgen receptor and estrogen receptor β genes.
91 citations
,
December 2017 in “Systems Biology in Reproductive Medicine” This meta-analysis found that lower serum SHBG levels are associated with an increased risk of PCOS, and improving SHBG levels through treatment may reduce PCOS complications.
91 citations
,
May 2005 in “The Journal of Clinical Endocrinology & Metabolism” In this study, a novel mutation in the glucocorticoid receptor gene was identified in a young woman, impairing glucocorticoid signaling and leading to generalized glucocorticoid resistance.
90 citations
,
October 1998 in “Animal Reproduction Science” This study found that in captive mouflon rams, reproductive and physical maturation, marked by changes in hormone levels and physical attributes, progresses gradually across their life span, with sexual maturity tied closely to physical maturity.
90 citations
,
January 1979 in “International review of cytology” This chapter reviews the complexity of hair and wool follicle formation, emphasizing the importance of cytological studies to understand the relationship between cellular components.