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The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

Photobiomodulation therapy using red and near-infrared light can reduce inflammation and aid in healing various conditions.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Caffeine in cosmetics may reduce cellulite, protect skin, and stimulate hair growth, but more research is needed on its use and effects.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

Voriconazole can cause serious side effects, especially in long-term use.

Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.

Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

Vitiligo affects overall health and self-esteem, needing more research and awareness.

The circadian clock influences the behavior and regeneration of stem cells in the body.

New genes and pathways are important for testosterone production and male sexual development.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Nanotechnology in dermatology shows promise for better drug delivery and treatment effectiveness but requires more safety research.