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This study reviewed literature on reconstructive surgery, highlighting its role in restoring form and function after significant damage, and discussed common techniques, technological advancements like 3D printing, and challenges, including ethical and psychological considerations, emphasizing the importance of comprehensive patient care and expectation management.

This study found that Cepharanthine may mitigate doxorubicin-induced senescence by reducing SA-β-Gal activity and restoring autophagy in cell models, offering insights for antiaging drug development.

This study found that manipulating Wnt signaling pathways in cutaneous wounds can induce skin structures resembling regeneration, suggesting a potential role for Wnt signals in restoring skin architecture during wound healing.

This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.

In this study, increased corticosterone from chronic stress prolonged hair follicle stem cell quiescence in mice, inhibiting regeneration, but restoring Gas6 expression overcame this inhibition.

This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.

This review explores how epithelial cells from various niches in the skin respond and adapt during acute wound repair, highlighting the role of cellular plasticity in reepithelialization and restoring the skin's barrier function.

In this study, IFN-γ-stimulated iPSC-derived mesenchymal stem cell extracellular vesicles improved atopic dermatitis in mice by reducing Th2 cytokine activity, suppressing inflammation, and restoring skin barrier function, as evidenced by decreased itching and inflammatory markers.

In this study, tofacitinib treatment in a male patient with alopecia areata led to significant hair regrowth and improvement in nail dystrophy symptoms, restoring finger function within 10 months.

In this study, Cyanidin 3-O-arabinoside was found to protect against DHT-induced dermal papilla cell senescence and mitochondrial dysfunction in androgenetic alopecia, restoring hair growth in mouse models.

In this study, subcutaneous injection of bone marrow mesenchymal stem cells in burned rats significantly improved wound healing by reducing inflammation, scar formation, and wound size, and restoring normal skin structures.

This study developed a method to convert fibroblasts into sweat gland-like cells, suggesting potential for regenerating damaged skin and restoring sweat gland function.

This animal study found that intravenous administration of anionic squarticles, a lipid nanoemulsion, increased survival rates in rats with amitriptyline overdose by mitigating adverse effects and restoring normal blood pressure, highlighting its potential as a detoxifying antidote.

This study proposes a method for automatically removing hairs from skin lesion images by using edge-tangent flow for hair detection and texture synthesis for restoring occluded regions with minimal artifacts.

This study found that bioconjugating 16-methylheptadecanoic acid to damaged human hair can mimic the protective function of the original 18-methyleicosanoic acid, effectively restoring both the hair's external structural integrity and its internal moisture balance.

This study found that in mouse embryonic fibroblast cells lacking autophagy function, overexpression of Atg5 increased cell proliferation, while restoring autophagy reversed this effect, highlighting Atg5's dual role in tumorigenesis depending on autophagy conditions.

This study reports that aging in human skin involves early photo- and inflammation-related cellular changes, and suggests restoring KLF6 and HES1 expression might reverse some of these age-associated changes.

This review discusses regenerative therapy approaches, such as tissue stem cell transplantation and gene therapy, for restoring salivary gland function in xerostomia and reports no new research results.

This rat study found that a PLGA conduit filled with neural crest stem cells derived from hair follicles showed promising results in repairing peripheral nerve injuries, partially restoring sensory function and improving nerve structure.

This review of sequential immunotherapy strategies for alopecia areata suggests that combining initial intensive immunosuppression with maintenance therapy may effectively manage disease progression by modulating inflammation and restoring immune tolerance.

In this study, researchers developed a dissolvable microneedle patch combining HA-TEMPO and Portulaca oleracea L.-derived nanoparticles, which effectively reduced oxidative stress and inflammation in an atopic dermatitis model while restoring immune balance, suggesting a promising treatment strategy.

This study found that rhIL-15 promotes human hair follicle growth and regrowth in experimental settings and may have therapeutic potential for alopecia areata by restoring immune privilege guardianship.

In this study, the use of Selencin, both in tablet and peptide lotion form, over two months showed significant improvements in reducing hair loss and restoring hair structure and volume in patients with diffuse alopecia, with effects persisting up to four months after treatment.

In this study, researchers used a CRISPR-based method to correct mutations in the COL7A1 gene in stem cells from RDEB patients, restoring normal collagen expression in engineered skin grafts in mice.

This study found that shallot (Allium ascalonicum) extracts reduced oxidative stress in human nasal epithelial cells caused by PAH exposure by decreasing ROS generation, suppressing lipid peroxidation, and restoring SOD activity, with quercetin being a key antioxidant component.

This study reported that a new coating made with delaminated Ti₃C₂ MXene nano-sheets and a tea-derived compound effectively protects hair keratin from damage by providing UV screening, thermal dissipation, and antioxidation, while also enhancing mechanical strength and restoring wettability.

In this study, exosomes from hypoxia-conditioned mesenchymal stem cells significantly improved SOCS3 and STAT3 expression in a mouse model of androgenetic alopecia, suggesting they may offer a more effective therapeutic approach than minoxidil by restoring follicular homeostasis.

In this study, plerixafor was found to enhance melanogenesis and promote repigmentation by engaging a β-arrestin–β-catenin–MITF signaling axis in melanocytes, and showed effectiveness in restoring depigmentation in a murine model without causing systemic toxicity.

This study synthesized and compared single-ion doped silicate bioactive glass nanoparticles for tissue repair, finding that BSr and BCe were most effective in accelerating wound healing and restoring vasculature, with BSr particularly reducing inflammation and BCo enhancing hair follicle regeneration but with limited biosafety window.

This study found that the loss of ASLNC168501 accelerates hair follicle stem cell dysfunction in androgenetic alopecia through activation of the AR/miR-128-3p/IGF-1 pathway, suggesting that restoring ASLNC168501 could be a promising therapeutic strategy for hair regeneration.