Transplanted Epidermal Neural Crest Stem Cell in a Peripheral Nerve Gap

April 2014 in “ PubMed ”

Lu Zhang, Jieyuan Zhang, Bingcang Li, Zheng Liu, Bin Liu

epidermal neural crest stem cells EPI-NCSC hair follicles PLGA conduit sciatic nerve peripheral nerve injuries

TLDR Epidermal neural crest stem cells from hair follicles can help repair nerve injuries.

The study investigated the use of epidermal neural crest stem cells (EPI-NCSC) derived from hair follicles to repair peripheral nerve injuries. EPI-NCSC were cultured and then used to bridge a 10 mm gap in the sciatic nerve of rats using a PLGA conduit. The initial adhesion rate of EPI-NCSC on the PLGA membrane was 89.7%, with growth rates over several days showing consistent proliferation. After four weeks, the treated sciatic nerve showed histological restoration, partial recovery of sensory function, and an improved sciatic nerve index, indicating that EPI-NCSC in a PLGA conduit effectively repaired peripheral nerve injuries.

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