Prenatal Transplantation of Epidermal Neural Crest Stem Cells in Malformation of Cortical Development Mouse Model

December 2016 in “ Microscopy Research and Technique ”

Abdollah Omidi, Mohammad Esmaeil Akbari, Keywan Mortezaee, Ehsan Eqlimi, Cordian Beyer, Adib Zendedel, Iraj Ragerdi Kashani

epidermal neural crest stem cells EPI-NCSCs hair follicle bulges methylazoxymethanol MAM real-time PCR immunohistochemistry glial cells

TLDR EPI-NCSCs from hair follicles may help treat brain development issues in mice.

The study investigated the potential of prenatal transplantation of epidermal neural crest stem cells (EPI-NCSCs) from hair follicle bulges in treating malformations of cortical development (MCD) in a mouse model. Mice exposed to methylazoxymethanol (MAM) showed decreased thickness in various cerebral cortex areas, which was significantly improved in those treated with EPI-NCSCs, except for the corpus callosum. Real-time PCR and immunohistochemistry analyses indicated altered expression of neural and glial markers, suggesting that EPI-NCSCs could be a promising candidate for cell-based therapy in cortical injuries by influencing neural markers and their interaction with glial cells.

View this study on analyticalsciencejournals.onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Mouse Epidermal Neural Crest Stem Cell (EPI-NCSC) Cultures

14 citations , May 2008 in “Journal of Visualized Experiments”

Mouse epidermal neural crest stem cells can become various cell types and are easily obtained from hair follicles.

Related Community Posts Join

6 / 80 results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community 9months progress fin/derma pen/minoxidil

in Progress Pictures 1000 upvotes 5 years ago

A user's 9 month progress using Finasteride, Derma Pen/Roller and Minoxidil to treat hair loss. Replies in the conversation include advice on topical application of Minoxidil and Dutasteride for regrowth and hair thickness.

community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 249 upvotes 3 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community Clearing the air on how non-surgical treatments really work

17 upvotes 6 years ago

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

community Is tazarotene potentially better than tretinoin in combination with topical minoxidil?

in Chat 1 upvotes 1 week ago

Tazarotene may be more effective than tretinoin when combined with topical minoxidil for hair loss due to its selective binding to RAR-beta and gamma, though it can cause irritation. Tazarotene's potency can lead to indirect inflammatory reactions despite potentially causing less irritation than tretinoin.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 210 upvotes 10 months ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

Similar Research

5 / 1000+ results

Application of Second Near Infrared Fluorescence Imaging to Trace CelTrac1000-Labeled Hair Follicle Epidermal Neural Crest Stem Cells in Repairing Rat Facial Nerve Defects

research Application of Second Near Infrared Fluorescence Imaging to Trace CelTrac1000-Labeled Hair Follicle Epidermal Neural Crest Stem Cells in Repairing Rat Facial Nerve Defects

November 2023 in “Research Square (Research Square)”

NIR-II imaging effectively tracked stem cells that helped repair facial nerve defects in rats.

The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells

research The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells

5 citations , January 2023 in “Cell proliferation”

Chick embryo extract helps rat hair follicle stem cells potentially turn into Schwann cells, important for the nervous system.

Generation of Induced Pluripotent Stem Cells from Hair Follicle Bulge Neural Crest Stem Cells