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research Molecular heterogeneity of quiescent melanocyte stem cells revealed by single‐cell RNA‐sequencing
This study explored the diversity of melanocyte stem cell subpopulations in the hair follicles of adult female mice and identified novel groups with distinct immune privilege regulation, suggesting a heterogeneous landscape that future research should consider.
research Proteomic analysis of fetal skin by iTRAQ reveals molecular signals underlying Inner Mongolia Cashmere goat hair follicle initiation
This study identified proteins involved in hair follicle formation in cashmere goat embryos, highlighting potential signaling factors that may drive hair follicle initiation and cashmere growth.
research Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052
In this study, researchers found that an ethyl acetate extract of the green microalga Scenedesmus deserticola significantly increased the viability of human dermal fibroblasts by over 20% compared to a control and identified a potent anti-UV compound, loliolide, through further fractionation.
research 944 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration
This study identifies a mechanism where dsRNA activates TLR3 to induce RA production, promoting hair follicle regeneration in mice and suggesting a potential role in human tissue regeneration.
research Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats
In this study, researchers analyzed skin tissues from two types of Jinlan Cashmere Goats and identified crucial non-coding RNA mechanisms potentially impacting cashmere yield, revealing significant DE lncRNAs, mRNA expressions, and pathways relevant to cashmere quality improvement.
research Serenoa repens extracts promote hair regeneration and repair of hair loss mouse models by activating TGF-β and mitochondrial signaling pathway.
This study found that liposterolic extracts of Serenoa repens enhanced hair regeneration and repair in DHT-induced hair loss mouse models, suggesting potential effects comparable to finasteride.
research Integrative Proteo‐Transcriptomic Characterization of Androgenetic Alopecia Identifying ME1‐Mediated PPAR Signaling as a Potential Mediator
In this study, researchers performed the first integrated transcriptomic and proteomic analysis of scalp biopsies from male androgenetic alopecia patients, finding a significant association between PPAR signaling pathways and AGA, with ME1 identified as a key regulator in this process.
research Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation
This review explores the complex relationships between ferroptosis, anastasis, and chemoresistance in cancer therapy, highlighting the potential of combining ferroptosis with immunotherapy to overcome resistance and improve personalized cancer treatments.
research Mapping the accessibility of the disulfide crosslink network in the wool fiber cortex
In this study, researchers mapped cysteine accessibility in wool keratins and KAPs, revealing that certain cysteines in keratin end domains and Types I and II rod domains are accessible and likely involved in forming disulfide bonds.
research Genetic Fate Mapping Using Site-Specific Recombinases
This review discusses five genetic fate mapping methods used to study cell behaviors during development and regeneration, detailing the necessary tools and considerations without reporting new experimental results.
research 569 Application of 3D scaffold free dermal spheroids to investigate retinol and retinol alternatives mechanism of action on extracellular matrix
research Solid-Phase Microextraction and Related Techniques in Bioanalysis
This reprint reviews 14 papers on advances in solid-phase microextraction techniques for bioanalysis, reporting no new results.
research 1496 Transcription factor SOX2-induced amphiregulin inhibits pressure ulcer formation via suppressing oxidative stress after cutaneous ischemia-reperfusion in mice
This study found that inducing SOX2 in keratinocytes significantly reduced pressure ulcer formation after cutaneous ischemia-reperfusion injury by producing amphiregulin, which also reduced oxidative stress and apoptosis.
research Dynamic analysis of skin transcriptome in Xinjiang goats and functional verification of ELOVL3 in dermal papilla cell proliferation
This study investigated key genes associated with hair follicle cycle regulation and environmental adaptation in Xinjiang goats, highlighting ELOVL3's role in promoting dermal papilla cell proliferation under varying climates, potentially aiding in cashmere quality improvement and stress-resistant breeding.
research SOX9 as a key regulator of tissue remodelling and epithelial cell fate transitions.
In this review, the authors discuss how SOX9 functions as a key regulator of epithelial cell fate and tissue repair, suggesting its role in integrating environmental signals, which could inform regenerative medicine approaches despite potential risks like fibrosis and cancer.
research The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease
This article explores how the integrated stress response and senescence-associated secretory phenotype influence stem cell fate decisions, highlighting their dual roles in both protecting and disrupting stem cell integrity.
research Exosomes for Regeneration, Rejuvenation, and Repair
This review discusses the potential of exosomes and the secretome in stem cell-based regenerative therapies but reports no new experimental findings.
research Simultaneous Quantification of Dexpanthenol and Resorcinol from Hair Care Formulation Using Liquid Chromatography: Method Development and Validation
Researchers created a reliable method to measure dexpanthenol and resorcinol in hair products.
research Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation point between meibogenesis and sebogenesis
This study on Sdr16c5/Sdr16c6-null mice found that inactivating these genes significantly increased Meibomian gland secretions and altered lipid profiles but had a subtle impact on sebogenesis, suggesting the genes control a bifurcation point in meibogenesis pathways.
research Expression analysis of proteasome maturation protein (POMP) gene in Liaoning Cashmere goat
This study observed that POMP is strongly expressed in the root sheath hair follicles of Liaoning Cashmere goats and its expression can be regulated by certain factors, which may influence cashmere growth.
research 1410 Single-cell RNA sequencing reveals POUF51 and HES3 as regulators of the stem cell population in psoriasis
This research reexamined transcriptomic data to study stem and progenitor cell proliferation in psoriasis, finding that the number of committed progenitor cells increased eight-fold in psoriatic skin without altering stem cell numbers, potentially identifying new therapeutic targets.
research Functions of peroxisome proliferator‐activated receptors (PPAR) in skin homeostasis
This study suggests PPAR isotypes play distinct roles in skin, influencing epidermal barrier formation, sebocyte differentiation, and lipid production, with potential implications for treating skin disorders.
research Molecular Basis of Maintaining Circannual Rhythm in the Skin of Cashmere Goat
This study suggests that seasonal rhythm genes in cashmere goat skin are differentially expressed with changing daylight, potentially affecting hormone transformation and light sensitivity.
research 1497 Type 2-mediated oxidative reprogramming promotes the transition of macrophages into repair mode and is required for wound healing
This study identified a new role for IL-4Ra-induced oxidative metabolism in wound macrophages, essential for balancing inflammatory response and promoting pro-fibrotic repair, suggesting a target for fibrosis prevention.
research Molecular and cellular mechanisms of differentiation and plasticity processes to form adipocytes
This research found that human adipose stem cells maintained their immaturity and potential to differentiate into beige adipocytes in an endothelial growth medium, correlating with increased SOX2 expression linked to beige and brown adipocyte activation.
research Exosomes as Emerging Therapeutics in Aesthetic and Regenerative Medicine: A Scoping Review
This study explores the potential roles of exosomes in anti-aging applications, highlighting their ability to modulate inflammation, promote tissue regeneration, and transfer bioactive molecules to rejuvenate aging tissues and reverse cellular dysfunction.
research Isolation of sensory hair cell specific exosomes in human perilymph
This study successfully isolated inner ear-specific exosomes from perilymph samples of sensorineural hearing loss patients using a novel immunomagnetic approach, enabling groundbreaking liquid biopsy diagnostics.
research Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives
research Estudio de la reactividad de los anillos A y C de olean-12-enos naturales para la obtención de sintones quirales
This study isolated highly pure oleanolic and maslinic acids from olive milling residues, exploring their chemical reactions, including the formation of finasteride precursors.