This study found that while hydroxychloroquine was effective and safe for treating alopecia areata, patients using it experienced more relapses compared to those receiving betamethasone.
This study suggests that incorporating exogenous melatonin in the treatment of certain skin disorders, like psoriasis and eczema, can improve treatment efficiency, normalize immune parameters, and reduce disease relapses.
January 2011 in “Journal of The American Academy of Dermatology” Treating generalized granuloma annulare is difficult, with PUVA being the most effective option, but relapses are common.
191 citations
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May 2018 in “British journal of dermatology/British journal of dermatology, Supplement” This study reviewed recent theories on alopecia areata's pathogenesis, highlighting its autoimmune nature due to immune privilege disruption in hair follicles, and noted current treatments have limited efficacy with high relapse rates, underscoring the need for further research into its mechanisms for better therapies.
134 citations
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July 2020 in “Experimental dermatology” This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.
69 citations
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August 2006 in “Behavior Therapy” This study found that group behavior therapy for trichotillomania led to greater short-term symptom improvement compared to supportive therapy, but did not achieve clinically significant changes or prevent relapse over six months.
65 citations
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April 1999 in “Journal of Parasitology” This study found that all lesions in mice treated with a new topical formulation, WR 279,396, healed completely without relapse, outperforming other formulations and showing no toxicity.
63 citations
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April 1985 in “Journal of the American Academy of Dermatology” This study observed that topical PUVA treatment led to excellent or good hair regrowth in 45.4% of patients with alopecia areata, though many experienced relapse after treatment stopped.
50 citations
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January 2016 in “Journal of the American Academy of Dermatology” This systematic review of pulse corticosteroid therapy for alopecia areata found relatively low complete response rates, but responders experienced low relapse rates, indicating potential benefits for patients with favorable prognostic factors.
49 citations
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March 2017 in “Journal of the American Academy of Dermatology” This case series found that oral tofacitinib treatment in eight adolescents with alopecia universalis led to significant regrowth of hair, though relapse is likely after stopping therapy.
48 citations
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October 1996 in “Dermatologic clinics” This review discusses the variability and limitations of treatments for severe alopecia areata, noting some patients may achieve cosmetic hair regrowth with treatment, while others experience persistent hair loss or relapse.
46 citations
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October 2018 in “JCI insight” In this study, the researchers found that treatment with the JAK inhibitor tofacitinib in alopecia areata patients may reduce clonal CD8+ T cell expansions but does not eliminate them entirely, which could contribute to disease relapse.
41 citations
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November 2015 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This study found that diphenylcyclopropenone therapy resulted in over 50% hair regrowth in 71% of alopecia totalis patients, with a significant relapse association with thyroid disease, suggesting treatment could be viable but should continue for at least two years.
38 citations
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January 2013 in “Dermatology” This study found that intravenous high-dose pulse corticosteroids resulted in a complete response in 38% of children with alopecia areata, but the majority of responders relapsed within a year.
28 citations
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January 2016 in “Dermatology” This study observed that methotrexate combined with low- to moderate-dose oral corticosteroids may effectively treat severe alopecia areata, though long-term maintenance is often necessary due to relapse after tapering.
20 citations
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January 2014 in “Journal of Clinical & Experimental Dermatology Research” This study found that oral zinc sulphate was effective for treating patchy alopecia areata, with a low relapse rate observed after discontinuing treatment.
18 citations
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June 2020 in “Dermatologic Therapy” In this study, FCO2 laser treatment showed significantly better improvement for alopecia areata compared to traditional intralesional corticosteroid injections, with no serious side effects or relapse observed.
14 citations
,
January 2019 in “Annals of plastic surgery” This case report details a face and scalp transplant in a patient with granulomatosis with polyangiitis and trauma, showing an encouraging 3-year outcome without disease relapse or severe complications.
13 citations
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November 2012 in “Journal of The European Academy of Dermatology and Venereology” This study found that topical clobetasol propionate cream provided a modest improvement in hair regrowth for alopecia areata patients, though those with atopy had higher relapse rates after treatment completion.
12 citations
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March 2010 in “Revista iberoamericana de micología” This case report describes a Persian cat with dermatophytic pseudomycetoma that initially responded to griseofulvin treatment and surgical excision, but the condition relapsed, ultimately leading to the cat's death.
10 citations
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March 2019 in “Journal of Dermatological Treatment” In this study, participants with psoriasis vulgaris and chronic urticaria chose Chinese herbal medicine due to beliefs about its safety and effectiveness in preventing relapse, although convenience and clinical evidence remain important considerations.
8 citations
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June 2019 in “Journal of Cosmetic Dermatology” This study observed that combining nonablative fractional laser treatment with topical minoxidil led to hair regrowth in Chinese alopecia areata patients, noting complete regrowth in some patients and no relapse in the majority at a one-year follow-up, without reported side effects.
8 citations
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July 2018 in “The Journal of Dermatology” In this retrospective study, researchers observed that additional rounds of intravenous corticosteroid pulse therapy led to only partial hair regrowth in some rapidly progressive alopecia areata cases, with all participants experiencing relapse, indicating limited efficacy for severe cases resistant to initial treatment.
7 citations
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October 2012 in “PubMed” This study found that intralesional triamcinolone was more effective than topical anthralin in promoting hair regrowth in alopecia areata patients, but it also had a higher relapse rate.
6 citations
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July 2023 in “Journal of Drugs in Dermatology” This narrative review found that cryotherapy resulted in approximately 60% hair regrowth response in alopecia areata patients, with some evidence suggesting lower relapse rates compared to intralesional steroid injection, although no statistically significant difference in efficacy was identified.
6 citations
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January 2013 in “Journal of Veterinary Medical Science” This case study reported a Satsuma dog with alopecia and anemia improved with antiprotozoal treatment for Babesia gibsoni, but symptoms relapsed after discontinuation.
5 citations
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January 2024 in “Therapeutic Advances in Hematology” This report suggests an association between eosinophilic folliculitis and sustained complete response in a Sézary syndrome patient treated with mogamulizumab, although regular monitoring is necessary to prevent relapse.
5 citations
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September 1991 in “Veterinary dermatology” In this study of seborrhoeic dermatitis in pigmy goats, researchers found that the disease has chronic cycles of remission and relapse without clear infectious or nutritional causes, and corticosteroid treatment provided only temporary relief.
4 citations
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September 2010 in “Journal of Medical Case Reports” This case report documents a 57-year-old man with nephrotic syndrome linked to recurrent chronic graft-versus-host disease and lupus-like symptoms, with improvement after cyclosporin and steroids; however, he died later from leukemia relapse.
2 citations
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November 2023 in “Indian Dermatology Online Journal” In this case report, a 4-year-old Indian girl with linear and annular lupus panniculitis of the scalp achieved complete remission and hair regrowth with oral corticosteroids, showing no relapse after 6 months of follow-up.