Membranous Nephropathy and Lupus-Like Syndrome After Hematopoietic Cell Transplantation: A Case Report
September 2010
in “
Journal of Medical Case Reports
”
Studysummary This case report documents a 57-year-old man with nephrotic syndrome linked to recurrent chronic graft-versus-host disease and lupus-like symptoms, with improvement after cyclosporin and steroids; however, he died later from leukemia relapse.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
A 57-year-old Caucasian man developed nephrotic syndrome and a lupus-like syndrome after hematopoietic cell transplantation, despite initial improvement with cyclosporin and steroids, he eventually died from leukemia relapse. The case highlighted that chronic graft-versus-host disease can mimic systemic lupus erythematosus, presenting with symptoms like pancytopenia, hair loss, and positive anti-DNA antibodies, emphasizing the complexity of managing nephrotic syndrome post-transplantation while balancing immunosuppression and graft versus leukemia effect.
