Membranous Nephropathy and Lupus-Like Syndrome After Hematopoietic Cell Transplantation: A Case Report

    September 2010 in “ Journal of Medical Case Reports ”
    Kostas Stylianou, Stavros Stratakis, Vasiliki Mavroeidi, Ioannis Petrakis, Dimitris Xydakis, Eleftheria Vardaki, Spyros Stratigis, Kostas Perakis, Theodora Katsarou, Peggy Kanellou, Irene Xylouri, Constantina Petraki, Michael G. Alexandrakis, Eugene Daphnis
    TLDR A man developed autoimmune issues after a transplant, improved with treatment, but died from leukemia relapse.
    A 57-year-old Caucasian man developed nephrotic syndrome and a lupus-like syndrome after hematopoietic cell transplantation, despite initial improvement with cyclosporin and steroids, he eventually died from leukemia relapse. The case highlighted that chronic graft-versus-host disease can mimic systemic lupus erythematosus, presenting with symptoms like pancytopenia, hair loss, and positive anti-DNA antibodies, emphasizing the complexity of managing nephrotic syndrome post-transplantation while balancing immunosuppression and graft versus leukemia effect.
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