Androgenetic Alopecia: The Role of Inflammation and Demodex

    July 2001 in “ International Journal of Dermatology ”
    Larry E. Millikan
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    TLDR Inflammation and Demodex mites might contribute to hair loss, and targeting them could help treat it.
    Many papers suggest that inflammation and Demodex mites may play a role in androgenetic alopecia (AGA), a common form of hair loss. Studies have shown a correlation between Demodex density and hair loss severity in AGA patients, and treatments targeting inflammation and Demodex may be useful in treating AGA. However, further research is needed to fully understand the relationship between these factors and AGA, and to develop effective treatments.
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      community C’est terrible - at my wits end

      in Female  442 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Proposed new pathogenesis model for androgenetic alopecia (AGA)

      in Research/Science  8 upvotes 1 year ago
      The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

      community 1% cetirizine (available in allergy medicines) for androgenetic alopecia

       54 upvotes 5 years ago
      The conversation discusses using 1% cetirizine, an antihistamine, as a potential treatment for androgenetic alopecia (hair loss). One user plans to try cetirizine instead of finasteride, while others are curious or skeptical about its effectiveness, discussing the role of inflammation in hair loss.

      community For those dealing with an unbearable scalp itch/pressure/inflammation.

      in Treatment  8 upvotes 4 years ago
      The conversation discusses using cetirizine (Zyrtec) topically to relieve scalp itch associated with hair loss and suggests it may also benefit androgenetic alopecia (AGA). One person found relief from scalp itch after three months on finasteride, noting the itch was linked to areas where hair was lost.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  413 upvotes 2 weeks ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

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