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The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Removing Sprouty genes in mice causes various hormone-related issues but does not increase cancer risk by one year of age.

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Vitiligo affects overall health and self-esteem, needing more research and awareness.

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Removing anthrax toxin receptor 1 in pigs prevents Senecavirus A infection and causes a rare disease similar to GAPO syndrome.

Sorafenib can cause delayed skin problems, so patients need careful monitoring.

Adrenal disorders can cause lasting brain and behavior issues in children.

Anorexia Nervosa and Bulimia Nervosa are complex eating disorders with increasing incidence among young females, significant morbidity, and varying mortality rates, requiring more research for better treatment.

Lamins are vital for cell survival, organ development, and preventing premature aging.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Certain ESR1 gene variations may affect hormone levels and fat distribution in women with high male hormone levels.

Methylated flavonoids may effectively reduce depression and inflammation caused by finasteride.

Finasteride treatment in rats changed the expression of genes related to psychiatric and neurological functions, and these changes persisted after stopping the drug.

The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.

Non-coding RNAs could help detect and treat radiation damage.

Inhaling medicine may reduce side effects and improve treatment for a major lung cancer type.

FGF9 controls which receptors it binds to through a process where two FGF9 molecules join, and changes in FGF9 can lead to incorrect receptor activation.

Retinoic acid affects skin and hair health by working with specific receptors, and its absence can lead to hair loss and skin changes.

Zinc is essential for plant growth and human health, but many soils lack enough zinc, affecting crops and potentially leading to health problems.

Low zinc and selenium levels in sheep are linked to hair loss and thyroid problems.

New treatments for COVID-19 show promise, but more effective antiviral drugs are needed.

PEGylated liposomal doxorubicin improves cancer treatment effectiveness and reduces side effects like heart damage and hair loss.

Children with atopic dermatitis often have sleep problems, affecting their growth and behavior.

A Japanese patient with IFAP syndrome had a severe MBTPS2 gene mutation but showed milder symptoms than previously observed cases.

Histone modification is key in treating chronic inflammatory skin diseases.

LEF1 is essential for the development of airway glands and is regulated by the Wnt/ß-catenin pathway.