43 citations
,
July 1994 in “Journal of Cell Science” This study found that the extraction-resistant structures in hair, feathers, and hagfish teeth are due to ε-(γ-glutamyl)lysine cross-linked proteins, emphasizing their role in maintaining the integrity of these materials.
19 citations
,
July 1964 in “PubMed” This study observed that undifferentiated matrix cells at the base of the hair follicle differentiate into the medulla, cortex, cuticle, and inner root sheath cell types through specific morphological changes.
1 citations
,
December 2012 in “Clinical and Experimental Dermatology” This report describes a rare case of tumoral calcinosis presenting as a slow-growing mass on the scalp in an Afro-Caribbean man, with histopathology revealing calcium deposits and associated tissue changes.
191 citations
,
November 1959 in “Annals of the New York Academy of Sciences” This article reports electron microscope studies on the structure of hair and wool, but it does not present new clinical findings.
8 citations
,
April 2017 in “Journal of The Royal Society Interface” This study found that keratin intermediate filaments in the hair of GAN patients are altered, showing decreased diffraction signals and increased stiffness, strength, and extensibility.
August 2024 in “Research Journal of Health Sciences” This study reports that normal scalp and hair in Black Africans exhibited regular white dots and a preserved honeycomb pattern, with some showing peripilar casts and scales.
45 citations
,
February 2013 in “The Journal of Dermatology” This study seeks to clarify the terminology and classification of keratoacanthoma and similar squamous cell carcinoma lesions with central keratin-filled craters to aid in accurate differential diagnosis.
May 2020 in “International journal of dermatology and venereology” This study introduces the term "hair matrix cyst" for a cyst with both pilomatricoma and epidermal cyst characteristics, highlighting its potential for misdiagnosis among similar skin conditions.
1 citations
,
April 2019 in “PubMed” In this study, researchers found that papain-treated or mechanically altered Asian scalp hair fibers allowed for spontaneous ion movement and anthocyanin dye flow through the medulla tube, with dye flow enhanced by applied DC voltage.
41 citations
,
April 2009 in “Journal of comparative neurology” In this study, researchers observed that P2X3-immunoreactive fibers extensively innervate the epidermis of rats, suggesting a primary role in detecting noxious stimuli in cutaneous tissue.
November 2022 in “Journal of Investigative Dermatology” This study found that "early" transit amplifying cells, marked by CD271, are the first keratinocyte stem cell progenitors with distinct features, playing a significant role in early epidermal differentiation and regeneration.
30 citations
,
January 1999 in “Journal of Cutaneous Pathology” This study suggests that spiny keratoderma may be an ectopic hair formation on palms and soles, based on keratinization patterns observed using antikeratin antibodies and electron microscopy.
20 citations
,
November 2004 in “Archives of Pathology & Laboratory Medicine” This case report describes a rare instance of melanocytic matricoma, a benign pigmented papule found in sun-damaged skin of an elderly individual, highlighting its distinct clinical and pathological features.
2 citations
,
May 1979 in “PubMed” This report describes four cases of monilethrix in children and concludes that periodic inhibition of keratin synthesis, not a metabolic defect, may explain the hair abnormality.
106 citations
,
February 2014 in “eLife” This study concluded that terminal Schwann cells are essential for the maintenance and regeneration of mechanosensory lanceolate complexes at hair follicles in adult mice.
2 citations
,
July 2001 in “Dermatologic Surgery” This study reports two cases of trichoblastic neoplasms with histologic features suggesting they may be distinct, locally aggressive trichoblastic carcinomas separate from basal cell carcinoma.
March 2009 in “Chinese Journal of Dermatology” This study observed that melanocytes in the outer root sheath of fetal scalp hair follicles may act as stem cells, showing rapid proliferation but immature function and morphology in culture.
23 citations
,
June 1992 in “PubMed” This study found that RAR-gamma 1 mRNA is present in multiple skin layers and structures, suggesting a role in maintaining and differentiating normal epidermis and skin appendages.
63 citations
,
December 1998 in “Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology” The study improved understanding of keratin fiber structure by showing consistent microfibril diameter but varying distances and electron density profiles.
7 citations
,
January 1988 3 citations
,
January 1994 71 citations
,
February 1992 in “Journal of Cutaneous Pathology” This study found that monoclonal antibodies identified distinct staining patterns in benign and malignant skin appendage tumors, highlighting their potential as markers for analyzing skin tumors.
12 citations
,
January 1994 in “Dermatology” This study found that a patient with giant axonal degeneration had unique hair abnormalities such as trichorrhexis nodosa and altered S:N ratios, unlike her relatives but comparable to unrelated controls.
July 2021 in “Zurich Open Repository and Archive (University of Zurich)” This study provided new insights into the complex and heterogeneous architecture of keratin filaments, revealing their dynamic and flexible structure through cryo-electron microscopy analysis.
12 citations
,
January 1991 in “Acta Dermato Venereologica” The researchers reported that BCE-like changes overlying dermatofibroma show a differentiation pattern most similar to normal basal cells based on specific keratin markers.
5 citations
,
March 2013 in “Journal of Cutaneous Pathology” Granulomatous alopecia may be a distinct subtype of alopecia areata.
77 citations
,
April 2005 in “Journal of Investigative Dermatology” Repetin is a protein involved in skin and hair development, binding calcium and compensating for other proteins when needed.
This article reviews confocal microscopy findings in trichoepithelioma and desmoplastic trichoepithelioma, noting similarities with histological features, but it provides no new clinical results.
January 1999 in “Journal of the European Academy of Dermatology and Venereology” RAPK is a rare skin disorder with pigmented spots, mainly on hands and feet, starting in youth.
7 citations
,
January 1995 in “The Indian Journal of Animal Sciences” This study observed that buffalo teats have a melanin-rich epidermis, no hair follicles, and a complex structure with specific epithelial and muscular characteristics.