Studies on Monilethrix
May 1979
in “
PubMed
”
TLDR Monilethrix is not caused by a metabolic defect.
Monilethrix was a hair disorder characterized by fragile, beaded hair and baldness. In the study, four children exhibited irregular patterns of node and internode formation in their hair. Light microscopy suggested that periodic inhibition of keratin synthesis could explain the hair constrictions. Scanning electron microscopy revealed longitudinal ridging and surface irregularities in the hair internodes. Urine chromatography for argininosuccinic acid did not support the theory that monilethrix was a metabolic defect.
