This review indicates that glucagon-like peptide-1 receptor agonists may be linked to hair loss, raising safety concerns despite the lack of definitive causal evidence.
December 2024 in “The Eurasia Proceedings of Science Technology Engineering and Mathematics” This study found that levels of gamma-glutamyl cysteine synthetase (ꝩ-GCS) were significantly higher in PCOS patients, suggesting a key role of glutathione metabolism in the disease's progression.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This paper provides an auditable companion package for their exploratory re-analysis of miRNA dysregulation and target enrichment in female pattern hair loss cases, focusing on candidate-level results from a public dataset comparison between affected individuals and healthy controls.
1 citations
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October 2024 in “Cureus” This review suggests that platelet-rich plasma injections may be an effective treatment for greater trochanteric pain syndrome, but emphasizes the need for more high-quality trials to confirm these findings.
January 2020 in “ScholarWorks (Central Washington University)” This study suggests that NAG-1 overexpression may prevent some metabolic dysfunctions linked to polycystic ovary syndrome in a mouse model.
July 2025 in “Annals of Medicine” This study describes a planned multicenter randomized controlled trial to assess the safety, tolerability, and pharmacokinetics of subdermal gestrinone pellets in patients with deep infiltrative endometriosis-related pelvic pain, but it does not report any findings yet.
1 citations
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June 2023 in “Reproduction” This review discusses the role of microglia in mediating prenatal androgen effects on the female brain, potentially contributing to PCOS development and neuroendocrine dysfunctions, but reports no new results.
51 citations
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March 2004 in “Hormone and Metabolic Research” This study found that women with PCOS have higher ghrelin levels compared to controls, with ghrelin negatively correlating with BMI and insulin levels, suggesting its potential role in PCOS etiology.
84 citations
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December 2018 in “Genetics in Medicine” This article reviews evidence- and consensus-based recommendations for using pegvaliase in adults with PKU and reports no new clinical results.
9 citations
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March 2015 in “Journal of Microbiology and Biotechnology” This study found that ultra-high molecular weight poly-γ-glutamic acid promoted hair growth in telogenic C57BL/6 mice by inhibiting 5-alpha reductase activity and inducing the anagen phase.
January 2025 in “Journal of the European Academy of Dermatology and Venereology” The study by Godfrey et al. highlights a potential link between GLP-1 receptor agonists, specifically semaglutide and tirzepatide, and the risk of alopecia, emphasizing the need for further investigation and patient awareness.
2 citations
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December 2013 in “The Journal of Dermatology” This article is a letter to the editor about onychogryphosis associated with an elastic wire, and reports no new research findings.
October 2020 in “Clinical and Experimental Dermatology” Hair loss improved after removing pituitary tumor.
June 2003 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” GLABRA2 represses root hair formation by inhibiting a specific gene.
June 2026 in “Annals of Medicine and Surgery” This study highlights the approval of orforglipron under the FDA's National Priority Voucher program, emphasizing its significance as a convenient oral treatment option with beneficial effects on glycemic and lipid profiles for diabetes and obesity management.
2 citations
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May 2011 in “Journal of Clinical Oncology” This study found that paclitaxel poliglumex showed limited effectiveness and was relatively well tolerated in post-menopausal women with advanced NSCLC, suggesting further testing of this treatment may not be justified.
3 citations
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May 2021 in “International Journal of Endocrinology and Metabolism” This study found no association between serum concentrations of irisin or GIP and BMI in women with or without PCOS.
In this case study, a patient developed a rash consistent with acute generalized exanthematous pustulosis after increasing the dose of semaglutide, suggesting that the reaction was likely due to the excipient propylene glycol, highlighting the importance of ingredient analysis and multidisciplinary collaboration for patient safety.
April 2026 in “Journal of Clinical Medicine” This review summarizes recent research into the effects of GLP-1 receptor agonists on skin processes, noting potential benefits for wound healing but also potential cosmetic concerns like facial fat loss and decreased collagen, highlighting the need for more clinical studies to clarify their dermatological impact.
28 citations
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October 1992 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” In this study, Scalp Immersion Proxigraphy (SIP) was shown to produce more accurate measurements of linear hair growth rate than crude phototrichogram techniques, suggesting SIP's suitability for clinical trials monitoring hair growth.
7 citations
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October 2017 in “Journal of exotic pet medicine” This case report documents a 3-year-old guinea pig with hormonally active ovarian cysts, cystic endometrial hyperplasia, and bacterial endometritis associated with a uterine foreign body.
September 2003 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” GLABRA2 gene controls root-hair growth by regulating phospholipid signaling.
This study reports that a novel series of compounds can potently and selectively inhibit glycogen synthase kinase-3, which activates glycogen synthase in insulin receptor-expressing cells and primary rat hepatocytes.
10 citations
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June 2021 in “Journal of Investigative Dermatology” GNPTAB gene is crucial for normal hair color in humans and mice.
26 citations
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January 2016 in “Indian journal of endocrinology and metabolism” In this randomized trial, metformin and pioglitazone both improved certain clinical and metabolic indices in women with PCOS, with pioglitazone showing potential as an alternate treatment for those intolerant to metformin.
December 2025 in “Journal of Pharma Insights and Research.” This paper reviews the state of knowledge on injectable cryogels, highlighting their unique properties such as shape-memory and mechanical integrity, which allow for minimally invasive delivery via needles and potential applications in oncology and regenerative medicine.
June 2026 in “Biomolecules and Biomedicine” This study found that women with PCOS had higher levels of serum phoenixin isoforms, which correlated with reproductive and metabolic markers, suggesting these isoforms may have a potential diagnostic role.
35 citations
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July 2010 in “The FEBS journal” In this study, researchers identified a highly reactive, isozyme-specific sequence for TGase 3, contributing to understanding its distinct functional role and activity distribution in the mouse epidermis.
24 citations
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December 1957 in “Experimental Cell Research” This study observed that the glassy layer of hair follicles in guinea pigs consists of thick collagen-type fibrils organized into two distinct arrays, whereas in young mice, the fibrils are thinner and develop between the outer root sheath and fibroblasts.
1 citations
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August 2024 in “Pharmaceuticals” This study found that goat placenta extract, when combined with PEGylated liposomes and microspicule gel, significantly promoted hair regrowth in patients experiencing hair loss due to chemotherapy by enhancing hair cell proliferation without causing skin irritation over a 12-week application period.