Faculty Opinions Recommendation of Modulation of Phospholipid Signaling by GLABRA2 in Root-Hair Pattern Formation

    September 2003 in “ Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ”
    Yasounori Machida
    TLDR GLABRA2 gene controls root-hair growth by regulating phospholipid signaling.
    The study by Ohashi et al. identified the phospholipase Dzeta1 gene (AtPLDzeta1) as a direct target of the homeobox gene GLABRA2 (GL2) in Arabidopsis, which played a crucial role in root-hair pattern formation. GL2 acted as a negative regulator by repressing AtPLDzeta1, which is involved in phospholipid signaling crucial for hair cell development. The research demonstrated that ectopic expression of AtPLDzeta1 led to hair-like cell bulges, while its repression inhibited root-hair formation, suggesting that AtPLDzeta1 positively influenced root-hair development. This highlighted the importance of phospholipid signaling in the development of hair and non-hair epidermal cells.
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