The Associations Between Serum Concentrations of Irisin and Glucose-Dependent Insulinotropic Polypeptide with Body Mass Index Among Women with and Without Polycystic Ovary Syndrome

This study investigated the relationship between body mass index (BMI) and serum concentrations of irisin and glucose-dependent insulinotropic polypeptide (GIP) in 159 women with polycystic ovary syndrome (PCOS) and 82 healthy women. The results indicated that there were no significant linear or non-linear associations between irisin/GIP levels and BMI in both groups. Women with PCOS were younger and had a higher BMI compared to healthy women. The findings suggested that irisin and GIP were not linked to BMI in women with or without PCOS, contributing to the understanding of PCOS, insulin resistance, and obesity-related disorders. Further large cohort studies were recommended to confirm these results.