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This study found that dietary supplementation with collagen, chondroitin sulfate, low-molecular weight hyaluronic acid, Pycnogenol®, and coenzyme Q10 significantly improved skin hydration, elasticity, nail hardness, and hair condition in patients with age-related dermatological changes after 12 weeks.

In this study, oral Pycnogenol® intake was reported to significantly increase hair density and improve scalp microcirculation in Han Chinese menopausal women over six months.

This study observed that patients with alopecia areata in the U.S. have a higher prevalence of several chronic illnesses, including essential hypertension, compared to controls.

This study suggests that phloroglucinol may enhance anagen signaling and reduce oxidative stress-induced damage in human dermal papilla cells, offering a potential therapy for hair loss.

This study suggests that paeoniflorin's protective effects on brain astrocytes may be mediated by TSPO and neurosteroids biosynthesis.

This review discusses the pharmacological effects and potential mechanisms of procyanidins, noting its roles in antioxidation, cardiovascular protection, and more, but reports no new clinical results.

This study found that Physcion from Polygonum multiflorum may be an effective natural 5α-reductase inhibitor for treating androgenic alopecia by enhancing hair growth and improving follicle morphology in laboratory settings.

This review discusses the potential role of oxidative stress in hair graying and age-related alopecia, emphasizing the need for new strategies to counteract these effects, but reports no new results.

This review discusses the role of antioxidants in managing oxidative skin damage and reports no new results, emphasizing the need for understanding their mechanisms, limitations, and risks for safe use.

This study found that procyanidin oligomers, particularly dimers and trimers, significantly promoted hair growth in mice and hair epithelial cell cultures, suggesting potential use as hair growth agents.

This study found that procyanidin B-3, a compound isolated from barley extract, may promote hair growth by enhancing hair epithelial cell growth and counteracting TGF-β1's growth-inhibiting effects in vitro and in vivo.

In this study, 1% procyanidin B-2 tonic significantly increased the number of total and terminal hairs on the scalp of male participants compared to a placebo after 6 months of use.

This study suggests that topical procyanidin B-2 is safe for use as a hair growth agent, as it showed no mutagenic effects or significant irritation in a series of toxicological tests.

This study found that procyanidins effectively alleviate neuropathic pain in mice by significantly inhibiting MMP-9/2 activity.

This review discusses plant extracts for dermatological use, highlighting evidence that some can reduce edema in chronic venous insufficiency or help treat actinic keratoses, but it reports no new clinical results.

This study concludes that egg shell membrane hydrolysates, particularly Fraction I, may effectively mitigate UV-B radiation-induced wrinkles and promote skin collagen and hyaluronic acid production, suggesting potential use in functional cosmetics.

This study found that procyanidin oligomers from apples and barley may stimulate hair growth by promoting hair epithelial cell proliferation and protecting them from apoptosis via MEK activation in a murine model.

This study found that Bacillus/Trapa japonica fruit ferment filtrate extracts enhanced human hair follicle dermal papilla cell proliferation through the Akt/ERK/GSK-3β signaling pathway, suggesting potential benefits for alopecia treatment.

This review examines clinical trials on polyphenol-based therapies for dermatological conditions, suggesting potential benefits for anogenital warts, alopecia, and acne, but calls for more rigorous trials.

This review discusses the use of nutraceuticals in dermatology for preventing and reversing signs of skin aging, but it reports no new clinical results.

This study found that RCS-01 cell therapy for aged skin was well tolerated and associated with increased gene expression related to extracellular matrix homeostasis, suggesting potential skin improvement.

This review discusses various bioactive elements in cosmeceuticals, highlighting their potential benefits, such as anti-aging effects and skin tone improvement, while noting the growing demand due to safety concerns and expanding market opportunities.

This article discusses the increasing use of plant and plant extracts during pregnancy and lactation, highlighting user perceptions of their benefits and safety but does not present new research findings.

Cosmeceuticals may benefit skin health but need more research for efficacy and safety confirmation.

This study found that purified apple juice containing procyanidin B-2 promoted hair growth in both mouse models and human clinical trials for male pattern baldness.

This study highlighted the promising health benefits of taxifolin, a flavonoid with antioxidant, anti-inflammatory, and other protective effects found in foods like onions and milk thistle, though more research is needed to fully understand its mechanisms and safety for human therapeutic use.

This review explores the potential of microneedling as a drug delivery system for treating melasma, focusing on its mechanisms, safety, efficacy, and clinical advantages over conventional therapies like hydroquinone and lasers.

This study reviews the pharmacological potential of Bacopa monniera, highlighting its extensive therapeutic effects such as antioxidant, anti-inflammatory, and memory enhancement properties, which are primarily attributed to its diverse bioactive compounds.

This review focuses on cosmeceuticals, emphasizing the herbs used and their associated benefits and challenges, but reports no new experimental results.

This study found that Dendrobium sabin flower extracts, especially the methanolic one, demonstrated strong antioxidant and anti-aging properties without significant toxicity, suggesting its potential in treating photo-induced skin aging.