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Fungi-produced compounds can change plant root growth.

This study found that injecting drug users attending an oral substitution therapy center often experience skin lesions, which negatively impact their psychosocial health and quality of life.

This study established a sensitive and reproducible method for determining the levels of four organic solvents in finasteride raw materials, meeting the requirements of the Chinese Pharmacopeia.

This study found that palmitoylethanolamide may stimulate allopregnanolone synthesis and reduce oxidative stress in astrocytes through PPAR-α activation, suggesting a neuroprotective role.

This review discusses the influence of androgens on opioid-mediated effects and calls for further research into their role in sex differences and potential therapeutic options for chronic pain and substance use disorders.

This study concluded that THC and THCA incorporate into hair by a mechanism independent of hair pigmentation, likely influenced by indirect deposition via sebum and skin.

This chapter reviews secondary uses for various drugs, noting that some have regulatory approval, indicating verified safety and efficacy, while others lack approval despite strong evidence.

This review summarizes research finding over 150 new molecules with various biological activities from traditional herbal medicines studied in China, Mongolia, Uzbekistan, and Bangladesh.

In this study, researchers explored how digital influencers may promote self-medication, finding that while 75.7% of undergraduate health students believed influencers suggest medications for self-medication, 73.2% did not use medication recommended by influencers, highlighting a need for regulatory oversight on influencer-generated health advice.

This study highlights the essential role of plant bioactive compounds in human health, attributing their beneficial effects to various biological activities such as antioxidant, anticarcinogenic, and antimicrobial actions, which can aid in preventing or managing noncommunicable diseases, including autoimmune and neurodegenerative conditions.

This study found that golden silk mature silkworm powder improved cognition and neuron proliferation in mice, potentially by enhancing mitochondrial function and countering scopolamine-induced amnesia.

This review discusses three classes of thiazole-bearing compounds in drug development and presents preclinical findings but reports no new experimental results, highlighting the need for further drug discovery.

This article discusses how drug molecules integrate into hair fibers, focusing on biological transport mechanisms and physicochemical factors, but reports no new experimental findings.

In this study of transgender and gender-diverse adults, the researchers observed that one-third of those on psychotropic medications within two years of starting hormone therapy experienced psychotropic polypharmacy, with a significantly higher likelihood of potential drug-hormone interactions in this group.

Different medications can cause serious side effects in some people.

In this study, the ethanol extract of Tridax procumbens leaves exhibited antimicrobial activity against both Gram-positive and Gram-negative bacteria, with specific active compounds identified through GC-MS analysis that may contribute to its therapeutic potential.

Increasing TSPO in the brain may help improve memory problems.

This review discusses the development and potential therapeutic applications of adenosine receptor agonists and positive allosteric modulators, noting that while many clinical trials have been unsuccessful, initial results for new compounds are promising.

In this study, germ-free male mice showed altered levels of certain neuroactive steroids in the brain and periphery, suggesting microbiota may influence neuroendocrine pathways that support brain functioning.

In this study, adolescents with depressive symptoms were found to have higher urinary excretion rates of certain steroid metabolites, including corticosterone and adrenal hormones, and a specific metabolite ratio was identified as a potential biomarker for distinguishing these patients from healthy controls.

This study suggests that 5alpha-dihydroprogesterone could be an effective, non-sedative anticonvulsant for drug-resistant complex partial seizures, as observed in a rat model.

This study using high-performance liquid chromatography reported that mice with more diverse gut microbiota had higher levels of specific compounds in hair compared to those with less diversity, with stress affecting certain plasma levels.

This article reviews the discovery and various physiological effects of cyproterone acetate, reporting its established indications for several androgen-driven conditions but providing no new clinical data.

This study identified certain benzopyran derivatives with a bulky tert-butyloxycarbonylamino group as effective KATP channel openers that inhibit insulin secretion in rat pancreatic islets.

In this study, BPA rapidly increased dendritic spine and synapse densities in cultured rat hippocampal neurons, with involvement of estrogen receptors and ERK1/2 and p38 pathways, but disrupted dihydrotestosterone's effects on synaptic plasticity.

This review explores the medicinal potential of gymnosperm plants, such as Platycladus orientalis, Araucaria heterophylla, Cycas revoluta, Thuja occidentalis, and Juniperus virginiana, highlighting their therapeutic significance across various medical practices, including contemporary, folk, and traditional medicine.

This study found that acute sleep deprivation enhanced 5α-reductase expression and activity in the rat prefrontal cortex, and finasteride treatment reduced associated psychosis- and mania-like behaviors.

This narrative review highlights that endurance, skill-oriented athletes, and physique-oriented competitors such as bodybuilders face accelerated degradation of fillers and botulinum neurotoxin due to elevated basal metabolic rates and other factors, and raised concerns about psychological conditions like body dysmorphic disorder in these populations.

This article discusses challenges primary care physicians face in diagnosing and treating depression, noting that up to one-third of antidepressant prescriptions involve non-indicated use; it also introduces FDA-approved treatments, esketamine nasal spray, and brexanolone IV injection.

This review discusses the effects of neuroactive testosterone metabolites on CNS functions and suggests their potential as therapeutic options for neurological disorders, but reports no new clinical results.