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Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Skin RAGE levels are linked to inflammation and cell death.

The document concludes that the human keratin gene cluster is complex, with a need for updated naming to reflect over 50 functional genes important for hair and skin biology.

Microemulsions could improve how drugs are delivered and absorbed in the body.

Deleting Snai2 and Snai3 causes fatal autoimmunity.

LLLT helps treat hair loss by increasing blood flow, reducing inflammation, and stimulating growth factors.

A Chinese family had a child with a specific gene mutation causing vitamin D-resistant rickets, but the child improved with calcium and low-dose calcitriol.

Keratin is crucial for keeping skin cells healthy and its changes can lead to diseases and affect cell behavior.

Keratin structure in hair is stable at pH 5-6 but disrupts between pH 6-7.

Higher DHT levels are linked to fewer hypogonadism symptoms in men with normal testosterone levels.

AnnoPharma effectively identifies substances causing adverse drug reactions in medical abstracts.

There is an urgent need for better treatments for hair loss caused by chemotherapy.

Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.

A certain genetic variation is linked to a higher risk of polycystic ovarian syndrome.

Certain transcription factors are key in controlling skin stem cell behavior and could impact future treatments for skin repair and hair loss.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Hox genes control hair growth patterns in mammals by regulating stem cell activity in the skin.

A specific RNA molecule, circCOL1A1, affects the growth and quality of goat hair by interacting with miR-149-5p and influencing cell growth pathways.

Many people diagnosed with androgenic alopecia might actually have hidden scarring or inflammation.

Thymosin β4 helps increase hair growth in Cashmere goats.

Keratin extract from human hair was found to promote hair growth in mice.

Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.

The skin's basement membrane is specially designed to support different types of connections between skin layers and hair follicles.

Intralesional chemotherapy with 5-fluorouracil and methotrexate may worsen keratoacanthoma-type skin cancer in transplant patients.

TNF-alpha inhibitors can cause various immune-related skin issues.

The document explains the genetic causes and characteristics of inherited hair disorders.

New cytokine-targeted therapies show promise for treating alopecia areata.

Box A of HMGB1 can improve stem cell function, aiding anti-aging therapy.

FLCN helps control iron levels in cells.

The document says a skin condition called alopecia areata causes hair loss and stress, and is treated with strong skin creams, injections, or other therapies, but treatment success varies.