research Expression and Cellular Localization of Keratinocyte Growth Factor and Its Receptor in Human Hyperplastic Prostate Tissue
KGF and its receptor are found in enlarged prostate tissue and KGF strongly increases cell growth.
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research The Post-Finasteride Syndrome: Possible Etiological Mechanisms and Symptoms
Post-finasteride syndrome causes lasting sexual, mental, and physical issues, needing more research for solutions.
research Simultaneous Spectrophotometric Determination of Finasteride and Tadalafil in Recently FDA Approved Entadfi Capsules
The methods accurately measure finasteride and tadalafil in Entadfi™ capsules for quality control.
research Dutasteride Improves Nocturia but Does Not Lead to Better Sleep: Results from the REDUCE Clinical Trial
Dutasteride can reduce night-time urination but it doesn't improve sleep quality.
research Safety and Efficacy of Advanced and Targeted Acid α-Glucosidase (AT-GAA) (ATB200/AT2221) in ERT-Switch Nonambulatory Patients with Pompe Disease: Preliminary Results from the ATB200-02 Trial
The combination of tadalafil and finasteride improves urinary symptoms and erectile function in men with enlarged prostates.
research WS PRO 160 I 120 mg (A Combination of Sabal and Urtica Extract) in Patients with LUTS Related to BPH
WS PRO 160 I 120 mg effectively treats urinary symptoms from BPH with good safety and tolerability.
research Why Odds Ratios Can Be Tricky Statistics
Odds Ratios can be misleading; it's better to also present risk and Relative Risks for clarity.
research Finasteride Use During Pregnancy and Early Neonatal Outcome: A Case Report
Baby born healthy despite mom taking finasteride, but more research needed.
research Determination of the Potency of a Novel Saw Palmetto Supercritical CO2 Extract for 5α-Reductase Isoform II Inhibition Using a Cell-Free In Vitro Test System
The new saw palmetto extract effectively inhibits an enzyme linked to prostate enlargement and may be as good as standard treatments.
research Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid, and Carnitine-Containing Compound in Prostate and Hair Follicle Cell-Based Assays
The new compound was more effective than finasteride in reducing markers of hair loss and prostate issues in cell tests.
research Regarding Prostate-Specific Antigen: Let's Not Shoot the Messenger
The drugs finasteride and dutasteride reduce low-grade prostate cancers but may double the risk of high-grade cancers.
research Homologous Recombination Induced by Doxazosin Mesylate and Saw Palmetto in the Drosophila Wing-Spot Test
Doxazosin mesylate and saw palmetto cause genetic changes in fruit flies.
research 5α-Reductase Inhibitors: The Finasteride Story
Finasteride safely treats enlarged prostate and male-pattern baldness.
research Doxazosin and Finasteride Alone or in Combination: The PREDICT Study
Doxazosin alone or combined with finasteride improves prostate symptoms better than finasteride alone, without extra benefits.
research Clinical Use of 5α-Reductase Inhibitors
Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.
research Effect of Finasteride and/or Terazosin on Serum PSA: Results of VA Cooperative Study #359
Finasteride reduces PSA levels, terazosin doesn't affect them, and tracking prostate cancer in patients taking finasteride could be difficult.
![The Synthesis of (−)-4-Methyl-8-Chloro-Trans-1,2,3,4,4a,5,6,10b-Octahydrobenzo-[f]-Quinolin-3-One-[3-14C] (LY300502-14C) via a Circuitous Route](/images/research/73bab8dc-bdf0-45e3-8ef7-73d0d4b93cb1/small/21074.jpg)
research The Synthesis of (−)-4-Methyl-8-Chloro-Trans-1,2,3,4,4a,5,6,10b-Octahydrobenzo-[f]-Quinolin-3-One-[3-14C] (LY300502-14C) via a Circuitous Route
Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.
research Scientific Evaluation of a Unani Pharmacopoeia-Based Formulation on BPH in Animal Model
The Unani Pharmacopoeia-Based Formulation significantly improved symptoms of enlarged prostate in rats.
research Oral Presentations: Abstracts of the Urological Society of Australia and New Zealand Annual Scientific Meeting, Melbourne, Australia
Urologists should monitor mental health in patients taking finasteride due to potential links to suicidal thoughts, adjusting dosage or stopping use if necessary. More research is needed to confirm if finasteride causes these thoughts.
research 5-Alpha Reductase Inhibitor Related Litigation: A Legal Database Review
Most legal cases about 5α-reductase inhibitors, drugs for hair loss and prostate issues, complain about side effects and delayed cancer diagnosis, with most lawsuits settled out of court.
research Sexual, Physical, And Overall Adverse Effects In Patients Treated With 5α-Reductase Inhibitors: A Systematic Review And Meta-Analysis
Medications for hair loss and prostate issues can significantly increase the risk of sexual side effects and other negative symptoms.
research Acute Gross Hematuria: Etiology and Management
Most cases of visible blood in urine resolve on their own, but severe cases may need treatment.
research Targeting a Fibrotic Bottleneck May Provide an Opening in the Treatment of LUTS
New treatments targeting fibrosis could improve urinary symptoms in BPH.
research Pharmacophore and Atom-Based 3D QSAR Studies on the Novel 5-Alpha-Reductase Inhibitors
The developed model can predict effective 5-alpha-reductase enzyme inhibitors.
research Prescribing to Save Patients Money: Ethical Considerations
Doctors should prescribe cheaper, off-label medication and teach patients how to use it to save money ethically.
research Effects of 5-Alpha Reductase Inhibitors
5-alpha reductase inhibitors can cause sexual, neurologic, endocrine, and cardiovascular side effects, but these are rare and usually stop after ending treatment.
research Discriminating in Favor of or Against Men with Increased Risk of Finasteride-Related Side Effects?
Finasteride treats baldness but may cause lasting sexual side effects.
research Reversible Visual Loss Caused by Combination Therapy of Alfuzosin and Finasteride in a Patient with Uveitic Glaucoma
Taking alfuzosin and finasteride together caused temporary vision loss in a glaucoma patient, but switching to tamsulosin helped.
research Testosterone Metabolite Nonessential For Androgen Effects
The body's change of testosterone into DHT is not necessary for testosterone's muscle and sexual effects.
research Dutasteride: A Review of Its Use in the Management of Prostate Disorders
Dutasteride is effective for treating prostate enlargement and reducing related surgery risk, but is not approved for preventing prostate cancer.