Homologous Recombination Induced by Doxazosin Mesylate and Saw Palmetto in the Drosophila Wing-Spot Test

    October 2011 in “ JAT. Journal of applied toxicology/Journal of applied toxicology ”
    Katiane Cella Gabriel, Rafael Rodrigues Dihl, Maurı́cio Lehmann, Maria Luı́za Reguly, Marc François Richter, Heloı́sa Helena Rodrigues de Andrade
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    Saw Palmetto →

    a natural and far less effective alternative to Finasteride

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    Frontline, gold standard treatment for combatting androgenic alopecia

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    Studysummary This study found that finasteride was nongenotoxic in Drosophila, while doxazosin mesylate and saw palmetto induced homologous recombination, indicating potential genotoxic actions under the test conditions. Our plain-language summary of this paper — not a Tressless recommendation.
    The study assessed the genotoxic effects of doxazosin mesylate and saw palmetto, commonly used for treating benign prostatic hyperplasia (BPH), using the Drosophila wing-spot test. Finasteride was found to be nongenotoxic, as it did not induce gene mutation, chromosomal mutation, or mitotic recombination. However, doxazosin mesylate and saw palmetto significantly increased spot frequencies in trans-heterozygous flies, indicating they induced homologous recombination. This genotoxicity was linked to the loss of heterozygosity, as no increase in spot frequencies was observed in balancer-heterozygous flies.
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