Validated HPTLC Method for the Simultaneous Determination of Alfuzosin, Terazosin, Prazosin, Doxazosin, and Finasteride in Pharmaceutical Formulations

August 2014 in “ Analytical Chemistry Research ”

Tarek S. Belal, M.S. Mahrous, Magdi M. Abdel-Khalek, Hoda G. Daabees, Mona M. Khamis

TLDR Method can accurately measure five BPH drugs at once.

The article presents a validated HPTLC method for the simultaneous determination of five drugs prescribed for the treatment of benign prostatic hyperplasia (BPH): alfuzosin hydrochloride (ALF), terazosin hydrochloride (TER), prazosin hydrochloride (PRZ), doxazosin mesylate (DOX), and finasteride (FIN). The method was found to be simple, sensitive, and fast, and was validated according to the International Conference on Harmonization (ICH) guidelines. The proposed method showed good linearity and accuracy, and was found to be applicable for routine quality-control analysis purposes of any of the titled drugs in their pharmaceutical preparations.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Simultaneous Determination of Finasteride and Tamsulosin in Combined Dosage Form by Using RP-HPLC Method

5 citations, February 2014 in “Journal of Liquid Chromatography & Related Technologies”

Method accurately measures finasteride and tamsulosin in combined drug form.

Validated RP-HPLC and TLC Methods for Simultaneous Estimation of Tamsulosin Hydrochloride and Finasteride in Combined Dosage Forms

research Validated RP-HPLC and TLC Methods for Simultaneous Estimation of Tamsulosin Hydrochloride and Finasteride in Combined Dosage Forms

26 citations, June 2010 in “Acta Pharmaceutica”

Methods accurately measure tamsulosin hydrochloride and finasteride in combined dosages.

research Determination of Finasteride in Tablets by High Performance Liquid Chromatography

13 citations, January 2007 in “E-journal of Chemistry”

Found accurate way to measure finasteride in tablets.

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

1707 citations, December 2003 in “The New England Journal of Medicine”

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

Related Community Posts Join

6 / 1000+ results

community A little inspiration for my 18 year old balders. Left is 18 year old me right one is 24 year old me. Only propecia 1 mg daily never miss it.

in Progress Pictures 172 upvotes 2 weeks ago

The conversation discusses the positive effects of taking finasteride (Propecia) for hair loss, with users sharing experiences of minimal side effects and improved hair growth over several years. The original poster emphasizes the importance of consistent use and mentions using Nizoral shampoo occasionally.

community Father trying to save his 17 year old son from MPB

in Progress Pictures 160 upvotes 2 years ago

Father assists son with hair loss using Finasteride Propecia. Son's hair improves, considers adding Minoxidil or Dutasteride for better results.

community Good hair days; finastride

in Finasteride/Dutasteride 15 upvotes 3 years ago

The user expresses positivity about managing hair loss and celebrates good hair days. They mention using finasteride (Propecia) as part of their treatment.

community If you’re sitting there wondering, “I’m losing my hair, what do I do?” then read my advice here. I’ve been fighting the fight for 7 years, with great success. (pictures included)

in Question 106 upvotes 11 years ago

Fighting hair loss with "The Big 3" treatments of Propecia, Rogaine and Nizoral shampoo, as well as specific advice on how to use these products. People have shared their long-term success stories and some have discussed the side effects of finasteride. Other suggestions included Lipogaine and Pura D'or Hair Loss Prevention Therapy Shampoo & Conditioner.

community To anyone starting their hair loss battles. [Sorry for long post]

6 upvotes 10 years ago

The user recommends using Regenepure (keto shampoo), Lipogaine (minoxidil), and NatureMade Biotin pills for hair loss treatment and advises against taking finasteride (propecia) without considering potential side effects. They share their own experience with these treatments and suggest reading about both the benefits and risks before deciding on finasteride.

community Guide To Finasteride and Avoiding Side Effects

in Finasteride/Dutasteride 25 upvotes 2 years ago

The conversation provides a guide on using finasteride for hair loss, suggesting to start with a quarter of a 1mg pill daily after ensuring estradiol levels are within a specific range, and potentially increasing the dose if no side effects occur. It also recommends supplements like DIM, Calcium d-glucarate, and Zinc to manage high estradiol levels and side effects from finasteride.

Related Research

1 / 1 results

Validated HPTLC Method for the Simultaneous Determination of Alfuzosin, Terazosin, Prazosin, Doxazosin, and Finasteride in Pharmaceutical Formulations

research Validated HPTLC Method for the Simultaneous Determination of Alfuzosin, Terazosin, Prazosin, Doxazosin, and Finasteride in Pharmaceutical Formulations

26 citations, August 2014 in “Analytical Chemistry Research”

Method can accurately measure five BPH drugs at once.