Validated HPTLC Method for the Simultaneous Determination of Alfuzosin, Terazosin, Prazosin, Doxazosin, and Finasteride in Pharmaceutical Formulations

August 2014 in “ Analytical Chemistry Research ”

Tarek S. Belal, M.S. Mahrous, Magdi M. Abdel-Khalek, Hoda G. Daabees, Mona M. Khamis

TLDR Method can accurately measure five BPH drugs at once.

The article presents a validated HPTLC method for the simultaneous determination of five drugs prescribed for the treatment of benign prostatic hyperplasia (BPH): alfuzosin hydrochloride (ALF), terazosin hydrochloride (TER), prazosin hydrochloride (PRZ), doxazosin mesylate (DOX), and finasteride (FIN). The method was found to be simple, sensitive, and fast, and was validated according to the International Conference on Harmonization (ICH) guidelines. The proposed method showed good linearity and accuracy, and was found to be applicable for routine quality-control analysis purposes of any of the titled drugs in their pharmaceutical preparations.

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Validated HPTLC Method for the Simultaneous Determination of Alfuzosin, Terazosin, Prazosin, Doxazosin, and Finasteride in Pharmaceutical Formulations

research Validated HPTLC Method for the Simultaneous Determination of Alfuzosin, Terazosin, Prazosin, Doxazosin, and Finasteride in Pharmaceutical Formulations

26 citations, August 2014 in “Analytical Chemistry Research”

Method can accurately measure five BPH drugs at once.