Targeting a Fibrotic Bottleneck May Provide an Opening in the Treatment of LUTS
TLDR New treatments targeting fibrosis could improve urinary symptoms in BPH.
The editorial discussed the role of fibrosis in benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS), noting that current treatments are ineffective against fibrosis, which worsens urinary dysfunction. The authors emphasized the need for new antifibrotic treatments and advanced diagnostic tools to address inflammation-driven fibrosis in BPH/LUTS, and highlighted the importance of animal models for studying these mechanisms and testing therapies.
